Journal article
Structure of Cerebral Arterioles in Cystathionine β-Synthase-Deficient Mice
Circulation research, Vol.91(10), pp.931-937
11/15/2002
DOI: 10.1161/01.RES.0000041408.64867.1D
PMID: 12433838
Abstract
ABSTRACT—We examined effects of hyperhomocysteinemia on structure and mechanics of cerebral arterioles. We measured plasma total homocysteine (tHcy) and pressure, diameter, and cross-sectional area of the vessel wall in maximally dilated cerebral arterioles in heterozygous cystathionine β-synthase-deficient (CBS) mice and wild-type (CBS) littermates that were provided with drinking water that was unsupplemented (control diet) or supplemented with 0.5% l-methionine (high-methionine diet). Plasma tHcy was 5.0±1.1 μmol/L in CBS mice and 8.3±0.9 μmol/L in CBS mice (P <0.05 versus CBS mice) fed the control diet. Plasma tHcy was 17.2±4.6 μmol/L in CBS mice and 21.2±3.9 μmol/L in CBS mice (P <0.05) fed the high-methionine diet. Cross-sectional area of the vessel wall was significantly increased in CBS (437±22 μm) mice fed control diet and CBS (442±36 μm) and CBS (471±46 μm) mice fed high-methionine diet relative to CBS (324±18 μm) mice fed control diet (P <0.05). During maximal dilatation, the stress-strain curves in cerebral arterioles of CBS mice on control diet and CBS and CBS mice on high-methionine diet were shifted to the right of the curve in cerebral arterioles of CBS mice on control diet, an indication that distensibility of cerebral arterioles was increased in mice with elevated levels of plasma tHcy. Thus, hyperhomocysteinemia in mice was associated with hypertrophy and an increase in distensibility of cerebral arterioles. These findings suggest that hyperhomocysteinemia promotes cerebral vascular hypertrophy and altered cerebral vascular mechanics, both of which may contribute to the increased incidence of stroke associated with hyperhomocysteinemia.
Details
- Title: Subtitle
- Structure of Cerebral Arterioles in Cystathionine β-Synthase-Deficient Mice
- Creators
- Gary Baumbach - From the Departments of Pathology (G.L.B.) and Internal Medicine (C.D.S., S.R.L.), University of Iowa College of Medicine and Cardiovascular Center, Iowa City, Iowa; the Baylor Institute of Metabolic Disease (T.B.), Dallas, Tex; and the VA Medical Center (S.R.L.), Iowa City, IowaCurt SigmundTeodoro BottiglieriSteven Lentz
- Resource Type
- Journal article
- Publication Details
- Circulation research, Vol.91(10), pp.931-937
- Publisher
- American Heart Association, Inc
- DOI
- 10.1161/01.RES.0000041408.64867.1D
- PMID
- 12433838
- ISSN
- 0009-7330
- eISSN
- 1524-4571
- Language
- English
- Date published
- 11/15/2002
- Academic Unit
- Molecular Physiology and Biophysics; Hematology, Oncology, and Blood & Marrow Transplantation; Pathology; Fraternal Order of Eagles Diabetes Research Center; Neuroscience and Pharmacology; Internal Medicine
- Record Identifier
- 9984094634802771
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