Journal article
Structure of a modified nucleoside, 3'α-diethylphosphono-3'β-hydroxy-5'-O-tritylthymidine
Acta crystallographica. Section C, Crystal structure communications, Vol.50(2), pp.291-294
1994
DOI: 10.1107/S0108270193008662
PMID: 8148096
Abstract
The modified nucleoside of the title was synthesized by nucleophilic addition of lithium diethyl phosphite to the corresponding 3'-keto nucleoside under basic conditions. C--P bond formation resulted from attack on the alpha face, trans to C(5') and the thymine ring. One molecule of EtOH crystallized with the nucleoside (C33H37N2O8P.-C2H6O). Intermolecular hydrogen bonds were observed between the O atom of the alcohol and the O(3')hydroxyl H atom, and between the phosphoryl O atom, O(5), and the N(3) H atom of the thymine ring.
Details
- Title: Subtitle
- Structure of a modified nucleoside, 3'α-diethylphosphono-3'β-hydroxy-5'-O-tritylthymidine
- Creators
- M. A Capron - Univ. Iowa, dep. chemistry, Iowa City IA 52242, United StatesW. L Mceldoon - Univ. Iowa, dep. chemistry, Iowa City IA 52242, United StatesN. C Baenziger - Univ. Iowa, dep. chemistry, Iowa City IA 52242, United StatesD. F Wiemer - Univ. Iowa, dep. chemistry, Iowa City IA 52242, United States
- Resource Type
- Journal article
- Publication Details
- Acta crystallographica. Section C, Crystal structure communications, Vol.50(2), pp.291-294
- Publisher
- Blackwell
- DOI
- 10.1107/S0108270193008662
- PMID
- 8148096
- ISSN
- 0108-2701
- eISSN
- 1600-5759
- Language
- English
- Date published
- 1994
- Academic Unit
- Neuroscience and Pharmacology; Chemistry
- Record Identifier
- 9984216714202771
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