Journal article
Structure of toxic shock syndrome toxin 1
Biochemistry (Easton), Vol.32(50), pp.13761-13766
12/21/1993
DOI: 10.1021/bi00213a001
PMID: 8268150
Abstract
The three-dimensional structure of toxic shock syndrome toxin 1 (TSST-1) from Staphylococcus aureus has been determined and refined to an R value of 0.226 for data between 8- and 2.5-A resolution. Overall, the structure of TSST-1 is similar to that of another superantigen, staphylococcal enterotoxin B (SEB). The key differences between these molecules are in the amino termini and in the degree to which a long central helix is covered by surface loops. The region around the carboxyl end of this central helix is proposed to govern the superantigenic properties of TSST-1. An adjacent region along this helix is proposed to be critical in the ability of TSST-1 to induce toxic shock syndrome.
Details
- Title: Subtitle
- Structure of toxic shock syndrome toxin 1
- Creators
- G Sridhar Prasad - Department of Biochemistry, University of Minnesota Medical School, Minneapolis 55455Cathleen A EarhartDebra L MurrayRichard P NovickPatrick M SchlievertDouglas H Ohlendorf
- Resource Type
- Journal article
- Publication Details
- Biochemistry (Easton), Vol.32(50), pp.13761-13766
- Publisher
- United States
- DOI
- 10.1021/bi00213a001
- PMID
- 8268150
- ISSN
- 0006-2960
- eISSN
- 1520-4995
- Grant note
- AI-22159 / NIAID NIH HHS GM-46436 / NIGMS NIH HHS
- Language
- English
- Date published
- 12/21/1993
- Academic Unit
- Microbiology and Immunology; Internal Medicine
- Record Identifier
- 9984002376302771
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