Journal article
Structure predicts function: Combining non-invasive electrophysiology with in-vivo histology
NeuroImage (Orlando, Fla.), Vol.108, pp.377-385
03/01/2015
DOI: 10.1016/j.neuroimage.2014.12.030
PMCID: PMC4334663
PMID: 25529007
Abstract
We present an approach for combining high resolution MRI-based myelin mapping with functional information from electroencephalography (EEG) or magnetoencephalography (MEG). The main contribution to the primary currents detectable with EEG and MEG comes from ionic currents in the apical dendrites of cortical pyramidal cells, aligned perpendicularly to the local cortical surface. We provide evidence from an in-vivo experiment that the variation in MRI-based myeloarchitecture measures across the cortex predicts the variation of the current density over individuals and thus is of functional relevance. Equivalent current dipole locations and moments due to pitch onset evoked response fields (ERFs) were estimated by means of a variational Bayesian algorithm. The myeloarchitecture was estimated indirectly from individual high resolution quantitative multiparameter maps (MPMs) acquired at 800 mu m isotropic resolution. Myelin estimates across cortical areas correlated positively with dipole magnitude. This correlation was spatially specific: regions of interest in the auditory cortex provided significantly better models than those covering whole hemispheres. Based on the MPM data we identified the auditory cortical area TE1.2 as the most likely origin of the pitch ERFs measured by MEG. We can now proceed to exploit the higher spatial resolution of quantitative MPMs to identify the cortical origin of M/EEG signals, inform M/EEG source reconstruction and explore structure-function relationships at a fine structural level in the living human brain. (C) 2014 The Authors. Published by Elsevier Inc.
Details
- Title: Subtitle
- Structure predicts function: Combining non-invasive electrophysiology with in-vivo histology
- Creators
- Saskia Helbling - Goethe University FrankfurtSundeep Teki - Newcastle UniversityMartina F. Callaghan - Wellcome Centre for Human NeuroimagingWilliam Sedley - Newcastle UniversitySiawoosh Mohammadi - National Hospital for Neurology and NeurosurgeryTimothy D. Griffiths - Newcastle UniversityNikolaus Weiskopf - Wellcome Centre for Human NeuroimagingGareth R. Barnes - Wellcome Centre for Human Neuroimaging
- Resource Type
- Journal article
- Publication Details
- NeuroImage (Orlando, Fla.), Vol.108, pp.377-385
- Publisher
- Elsevier
- DOI
- 10.1016/j.neuroimage.2014.12.030
- PMID
- 25529007
- PMCID
- PMC4334663
- ISSN
- 1053-8119
- eISSN
- 1095-9572
- Number of pages
- 9
- Grant note
- LOEWE Grant "Neuronale Koordination Forschungsschwerpunkt Frankfurt (NeFF)" Wellcome Trust; European Commission MR/K005464/1 / Medical Research Council; UK Research & Innovation (UKRI); Medical Research Council UK (MRC); European Commission G.-A.-Lienert Stiftung MO 2397/1-1 / Deutsche Forschungsgemeinschaft (DFG); German Research Foundation (DFG) 616905 / European Research Council under the European Union; European Research Council (ERC) MR/K005464/1 / MRC; UK Research & Innovation (UKRI); Medical Research Council UK (MRC) MR/K005464/1 / MRC UK MEG Partnership Grant; UK Research & Innovation (UKRI); Medical Research Council UK (MRC)
- Language
- English
- Date published
- 03/01/2015
- Academic Unit
- Psychological and Brain Sciences
- Record Identifier
- 9984627311802771
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