Journal article
Structured sequence processing and combinatorial binding: neurobiologically and computationally informed hypotheses
Philosophical transactions of the Royal Society of London. Series B. Biological sciences, Vol.375(1791), pp.20190304-20190304
02/03/2020
DOI: 10.1098/rstb.2019.0304
PMCID: PMC6939361
PMID: 31840585
Abstract
Understanding how the brain forms representations of structured information distributed in time is a challenging endeavour for the neuroscientific community, requiring computationally and neurobiologically informed approaches. The neural mechanisms for segmenting continuous streams of sensory input and establishing representations of dependencies remain largely unknown, as do the transformations and computations occurring between the brain regions involved in these aspects of sequence processing. We propose a blueprint for a neurobiologically informed and informing computational model of sequence processing (entitled: Vector-symbolic Sequencing of Binding INstantiating Dependencies, or VS-BIND). This model is designed to support the transformation of serially ordered elements in sensory sequences into structured representations of bound dependencies, readily operates on multiple timescales, and encodes or decodes sequences with respect to chunked items wherever dependencies occur in time. The model integrates established vector symbolic additive and conjunctive binding operators with neurobiologically plausible oscillatory dynamics, and is compatible with modern spiking neural network simulation methods. We show that the model is capable of simulating previous findings from structured sequence processing tasks that engage fronto-temporal regions, specifying mechanistic roles for regions such as prefrontal areas 44/45 and the frontal operculum during interactions with sensory representations in temporal cortex. Finally, we are able to make predictions based on the configuration of the model alone that underscore the importance of serial position information, which requires input from time-sensitive cells, known to reside in the hippocampus and dorsolateral prefrontal cortex. This article is part of the theme issue 'Towards mechanistic models of meaning composition'.
Details
- Title: Subtitle
- Structured sequence processing and combinatorial binding: neurobiologically and computationally informed hypotheses
- Creators
- Ryan Calmus - Newcastle UniversityBenjamin Wilson - University of Newcastle AustraliaYukiko Kikuchi - Newcastle UniversityChristopher I. Petkov - University of Newcastle Australia
- Resource Type
- Journal article
- Publication Details
- Philosophical transactions of the Royal Society of London. Series B. Biological sciences, Vol.375(1791), pp.20190304-20190304
- Publisher
- Royal Soc London
- DOI
- 10.1098/rstb.2019.0304
- PMID
- 31840585
- PMCID
- PMC6939361
- ISSN
- 0962-8436
- eISSN
- 1471-2970
- Number of pages
- 13
- Grant note
- WT110198 / Sir Henry Wellcome Fellowship European Research Council; European Research Council (ERC); European Commission R01-DC04290 / NIH; United States Department of Health & Human Services; National Institutes of Health (NIH) - USA WT092606AIA / Wellcome Trust BB/J009849/1 / BBSRC; UK Research & Innovation (UKRI); Biotechnology and Biological Sciences Research Council (BBSRC)
- Language
- English
- Date published
- 02/03/2020
- Academic Unit
- Iowa Neuroscience Institute; Neurosurgery; Otolaryngology
- Record Identifier
- 9984360008102771
Metrics
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