Journal article
Studies of hyperlipidemia in drug-induced diabetic rats by high-performance liquid chromatography
Journal of chromatography. Biomedical applications, Vol.221(1), pp.19-26
1980
DOI: 10.1016/S0378-4347(00)81003-8
Abstract
A hyperlipidemic condition is often associated with diabetes. The possibility that specific serum lipids (i.e., individual triglycerides or cholesterol esters) may be altered in the diabetic state was investigated. Serum lipids from both controls and streptozotocin- and alloxantreated rats were separated into approximately twenty chromatographic fractions by reversed-phase high-performance liquid chromatography; a number of individual triglycerides and cholesterol esters were identified. The methodology described allowed subtle changes in individual lipid components to be detected. Only minor variations in the cholesterol and cholesterol ester fractions were observed between the control and diabetic samples. While not uniform throughout, elevations in the triglyceride fractions occurred in the diabetics. Also, differences in triglyceride content were found to exist between the groups of streptozotocin- and alloxan-treated animals.
Details
- Title: Subtitle
- Studies of hyperlipidemia in drug-induced diabetic rats by high-performance liquid chromatography
- Creators
- Sharon L Smith - Indiana UniversityMilos Novotný - Indiana UniversitySteven A Moore - Purdue University West LafayetteDavid L Felten - Purdue University West Lafayette
- Resource Type
- Journal article
- Publication Details
- Journal of chromatography. Biomedical applications, Vol.221(1), pp.19-26
- DOI
- 10.1016/S0378-4347(00)81003-8
- ISSN
- 0378-4347
- Publisher
- Elsevier B.V
- Language
- English
- Date published
- 1980
- Academic Unit
- Pathology
- Record Identifier
- 9984186561502771
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