Study of amyloid-β peptide functional brain networks in AD, MCI and HC

Jiehui Jiang; Huoqiang Duan; Zheming Huang; Zhihua Yu; Alzheimer's Disease Neuroimaging Initiative

doi:10.3233/BME-151525

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Study of amyloid-β peptide functional brain networks in AD, MCI and HC

Journal article

Peer reviewed

Study of amyloid-β peptide functional brain networks in AD, MCI and HC

Jiehui Jiang, Huoqiang Duan, Zheming Huang, Zhihua Yu and Alzheimer's Disease Neuroimaging Initiative

Bio-medical materials and engineering, Vol.26 Suppl 1, pp.S2197-S2205

2015

DOI: 10.3233/BME-151525

PMID: 26405999

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Abstract

One medical challenge in studying the amyloid-β (Aβ) peptide mechanism for Alzheimer's disease (AD) is exploring the law of beta toxic oligomers' diffusion in human brains in vivo. One beneficial means of solving this problem is brain network analysis based on graph theory. In this study, the characteristics of Aβ functional brain networks of Healthy Control (HC), Mild Cognitive Impairment (MCI), and AD groups were compared by applying graph theoretical analyses to Carbon 11-labeled Pittsburgh compound B positron emission tomography (11C PiB-PET) data. 120 groups of PiB-PET images from the ADNI database were analyzed. The results showed that the small-world property of MCI and AD were lost as compared to HC. Furthermore, the local clustering of networks was higher in both MCI and AD as compared to HC, whereas the path length was similar among the three groups. The results also showed that there could be four potential Aβ toxic oligomer seeds: Frontal_Sup_Medial_L, Parietal_Inf_L, Frontal_Med_Orb_R, and Parietal_Inf_R. These four seeds are corresponding to Regions of Interests referred by physicians to clinically diagnose AD.

Cognitive Dysfunction - metabolism

Humans

Male

Positron-Emission Tomography

Cognitive Dysfunction - pathology

Alzheimer Disease - pathology

Brain - metabolism

Alzheimer Disease - metabolism

Amyloid beta-Peptides - metabolism

Aged, 80 and over

Brain - pathology

Female

Aged

Details

Title: Subtitle: Study of amyloid-β peptide functional brain networks in AD, MCI and HC
Creators: Jiehui Jiang - Institute of Biomedical Engineering, School of Communication and Information Technology, Shanghai University, Shanghai, China
Huoqiang Duan - Institute of Biomedical Engineering, School of Communication and Information Technology, Shanghai University, Shanghai, China
Zheming Huang - PET Center, Huashan Hospital, Fudan University, Shanghai, China
Zhihua Yu - Shanghai Geriatric Institute of Chinese Medicine, Shanghai, China
Alzheimer's Disease Neuroimaging Initiative
Contributors: Laura L Boles-Ponto (Contributor) - University of Iowa, Radiology
Resource Type: Journal article
Publication Details: Bio-medical materials and engineering, Vol.26 Suppl 1, pp.S2197-S2205
DOI: 10.3233/BME-151525
PMID: 26405999
NLM abbreviation: Biomed Mater Eng
eISSN: 1878-3619
Publisher: Netherlands
Grant note: U01 AG024904 / NIA NIH HHS
Language: English
Date published: 2015
Academic Unit: Radiology; Pharmaceutical Sciences and Experimental Therapeutics
Record Identifier: 9984051730802771

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