Sub-retinal pigment epithelium tubules in non-neovascular age-related macular degeneration

Serena Fragiotta; Mariacristina Parravano; Riccardo Sacconi; Eliana Costanzo; Daniele De Geronimo; Francesco Prascina; Vittorio Capuano; Eric H. Souied; Ian C. Han; Robert Mullins; Giuseppe Querques

doi:10.1038/s41598-022-19193-6

Back

Sub-retinal pigment epithelium tubules in non-neovascular age-related macular degeneration

Journal article

Open access

Peer reviewed

Sub-retinal pigment epithelium tubules in non-neovascular age-related macular degeneration

Serena Fragiotta, Mariacristina Parravano, Riccardo Sacconi, Eliana Costanzo, Daniele De Geronimo, Francesco Prascina, Vittorio Capuano, Eric H. Souied, Ian C. Han, Robert Mullins, …

Scientific reports, Vol.12(1), pp.1-11

09/01/2022

DOI: 10.1038/s41598-022-19193-6

PMCID: PMC9452588

PMID: 36071082

Files and links (1)

url

https://doi.org/10.1038/s41598-022-19193-6View

Published (Version of record) Open Access

Abstract

Abstract To describe a novel optical coherence tomography (OCT) signature resembling sub-retinal pigment epithelium (RPE) tubules (SRT) in non-neovascular age-related macular degeneration (AMD). Patients suffering from non-neovascular AMD with complete medical records and multimodal imaging were retrospectively revised in three different tertiary care centers. Multimodal imaging included color fundus photograph, spectral-domain OCT (Spectralis, Heidelberg Engineering, Germany), fundus autofluorescence, OCT angiography (RTVue XR Avanti, Optovue, Inc., Fremont, CA). A total of 7 eyes of 7 patients with drusenoid pigment epithelium detachment (PED) were consecutively analyzed. The sub-RPE tubules appeared as ovoidal structures with a hyperreflective contour and hyporeflective interior appreciable in the sub-RPE-basal lamina (BL) space on OCT B-scan. The anatomical location of the sub-RPE formations was lying above the Bruch’s membrane in 5/7 cases (71.4%) or floating in the sub-RPE-BL space in 2/7 cases (28.6%). En-face OCTA revealed a curvilinear tubulation-like structure corresponding to SRT without flow signal. Sub-RPE tubules represent a newly identified OCT signature observed in eyes with drusenoid PED. The presumed origin may include a variant of calcified structure or alternatively activated RPE cells with some residual BL or basal laminar deposits attracted to BrM for craving oxygen.

Details

Title: Subtitle: Sub-retinal pigment epithelium tubules in non-neovascular age-related macular degeneration
Creators: Serena Fragiotta - Saint Camillus International University of Health and Medical Sciences
Mariacristina Parravano - IRCCS-Fondazione Bietti
Riccardo Sacconi - IRCCS Ospedale San Raffaele
Eliana Costanzo - IRCCS-Fondazione Bietti
Daniele De Geronimo - IRCCS-Fondazione Bietti
Francesco Prascina - IRCCS Ospedale San Raffaele
Vittorio Capuano - Hôpital Intercommunal de Créteil
Eric H. Souied - Hôpital Intercommunal de Créteil
Ian C. Han - University of Iowa
Robert Mullins - University of Iowa
Giuseppe Querques - IRCCS Ospedale San Raffaele
Resource Type: Journal article
Publication Details: Scientific reports, Vol.12(1), pp.1-11
DOI: 10.1038/s41598-022-19193-6
PMID: 36071082
PMCID: PMC9452588
NLM abbreviation: Sci Rep
eISSN: 2045-2322
Publisher: Nature Portfolio
Language: English
Date published: 09/01/2022
Academic Unit: Ophthalmology and Visual Sciences
Record Identifier: 9984296002202771

Metrics

18 Record Views

2 Times Cited - Web of Science