Journal article
Subacute Sclerosing Panencephalitis Manifesting as Viral Retinitis: Clinical and Histopathologic Findings
American journal of ophthalmology, Vol.123(4), pp.533-542
04/1997
DOI: 10.1016/S0002-9394(14)70179-5
PMID: 9124250
Abstract
To describe the clinical and histopathologic features of a patient with viral retinitis secondary to subacute sclerosing panencephalitis.
The patient was a human immunodeficiency virus-negative intravenous drug abuser with an acute retinitis that later progressed to encephalitis despite aggressive treatment for possible viral, protozoal, bacterial, and rickettsial infections. The patient had many of the characteristic findings of subacute sclerosing panencephalitis, including a history of measles in early childhood, myoclonus, periodic complexes on electroencephalographic testing, persistently elevated serum and cerebrospinal fluid antimeasles immunoglobulin G (IgG) titers, and a cerebrospinal fluid oligoclonal IgG gammopathy. Ultrastructural examination demonstrated numerous filamentous microtubular intranuclear viral inclusions in the nuclear layers of the retina consistent with the measles virus. This case is unusual in that our patient developed subacute sclerosing panencephalitis later in life and because there was an 8-year period between presumed viral infections in the two eyes.
An acute retinitis in an intravenous drug abuser is not always caused by human immunodeficiency virus-related infections; not all viral retinitis responds to therapy; and mortality as well as the usual morbidity may be associated with viral retinitis. One might consider the diagnosis of subacute sclerosing panencephalitis in a young person with an acute retinitis with little or no vitreal inflammation and lack of response to anti-cytomegalovirus and antitoxoplasmosis therapy.
Details
- Title: Subtitle
- Subacute Sclerosing Panencephalitis Manifesting as Viral Retinitis: Clinical and Histopathologic Findings
- Creators
- DONALD W PARK - Department of Ophthalmology, University of Iowa Hospitals and Clinics, Iowa City, IowaH. CULVER BOLDT - Department of Ophthalmology, University of Iowa Hospitals and Clinics, Iowa City, IowaSTEPHEN J MASSICOTTE - Departments of OphthalmologyEFFIONG E.U AKANG - Pathology and Laboratory MedicineKAREN L ROOS - Neurology, Indiana University Medical Center, Indianapolis, IndianaADRIANA BODNAR - Pathology and Laboratory MedicineJOHN PLESS - Pathology and Laboratory MedicineBERNARDINO GHETTI - Pathology and Laboratory MedicineROBERT M PASCUZZI - Neurology, Indiana University Medical Center, Indianapolis, Indiana
- Resource Type
- Journal article
- Publication Details
- American journal of ophthalmology, Vol.123(4), pp.533-542
- Publisher
- Elsevier Inc
- DOI
- 10.1016/S0002-9394(14)70179-5
- PMID
- 9124250
- ISSN
- 0002-9394
- eISSN
- 1879-1891
- Language
- English
- Date published
- 04/1997
- Academic Unit
- Ophthalmology and Visual Sciences
- Record Identifier
- 9984083830102771
Metrics
23 Record Views