Subarachnoid Hemorrhage International Trialists Data Repository (SAHIT)

R. Loch Macdonald; Michael D Cusimano; Nima Etminan; Daniel Hanggi; David Hasan; Don Ilodigwe; Blessing Jaja; Hector Lantigua; Peter Le Roux; Benjamin Lo; Ada Louffat-Olivares; Stephan Mayer; Andrew Molyneux; Audrey Quinn; Tom A Schweizer; Thomas Schenk; Julian Spears; Michael Todd; James Torner; Mervyn D.I Vergouwen; George K.C Wong; SAHIT Collaboration

doi:10.1016/j.wneu.2013.01.006

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Subarachnoid Hemorrhage International Trialists Data Repository (SAHIT)

Journal article

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Subarachnoid Hemorrhage International Trialists Data Repository (SAHIT)

R. Loch Macdonald, Michael D Cusimano, Nima Etminan, Daniel Hanggi, David Hasan, Don Ilodigwe, Blessing Jaja, Hector Lantigua, Peter Le Roux, Benjamin Lo, …

World neurosurgery, Vol.79(3-4), pp.418-422

03/2013

DOI: 10.1016/j.wneu.2013.01.006

PMID: 23295631

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Abstract

The outcome of patients with aneurysmal subarachnoid hemorrhage (SAH) has improved slowly over the past 25 years. This improvement may be due to early aneurysm repair by endovascular or open means, use of nimodipine, and better critical care management. Despite this improvement, mortality remains at about 40%, and many survivors have permanent neurologic, cognitive, and neuropsychologic deficits. Randomized clinical trials have tested pharmacologic therapies, but few have been successful. There are numerous explanations for the failure of these trials, including ineffective interventions, inadequate sample size, treatment side effects, and insensitive or inappropriate outcome measures. Outcome often is evaluated on a good-bad dichotomous scale that was developed for traumatic brain injury 40 years ago. To address these issues, we established the Subarachnoid Hemorrhage International Trialists (SAHIT) data repository. The primary aim of the SAHIT data repository is to provide a unique resource for prognostic analysis and for studies aimed at optimizing the design and analysis of phase III trials in aneurysmal SAH. With this aim in mind, we convened a multinational investigator meeting to explore merging individual patient data from multiple clinical trials and observational databases of patients with SAH and to create an agreement under which such a group of investigators could submit data and collaborate. We welcome collaboration with other investigators.

Clinical trial

Cerebral aneurysm

Subarachnoid hemorrhage

Outcome

Details

Title: Subtitle: Subarachnoid Hemorrhage International Trialists Data Repository (SAHIT)
Creators: R. Loch Macdonald - St. Michael's Hospital, University of Toronto, Toronto, Ontario, Canada
Michael D Cusimano - St. Michael's Hospital, University of Toronto, Toronto, Ontario, Canada
Nima Etminan - Heinrich Heine University, Düsseldorf, Germany
Daniel Hanggi - Heinrich Heine University, Düsseldorf, Germany
David Hasan - University of Iowa, Iowa City, Iowa, USA
Don Ilodigwe - St. Michael's Hospital, University of Toronto, Toronto, Ontario, Canada
Blessing Jaja - St. Michael's Hospital, University of Toronto, Toronto, Ontario, Canada
Hector Lantigua - Columbia University, New York, New York, USA
Peter Le Roux - University of Pennsylvania, Philadelphia, Pennsylvania, USA
Benjamin Lo - St. Michael's Hospital, University of Toronto, Toronto, Ontario, Canada
Ada Louffat-Olivares - St. Michael's Hospital, University of Toronto, Toronto, Ontario, Canada
Stephan Mayer - Columbia University, New York, New York, USA
Andrew Molyneux - Oxford University, Oxford, United Kingdom
Audrey Quinn - The General Infirmary, Leeds, Leeds, United Kingdom
Tom A Schweizer - St. Michael's Hospital, University of Toronto, Toronto, Ontario, Canada
Thomas Schenk - King's College London, London, United Kingdom
Julian Spears - St. Michael's Hospital, University of Toronto, Toronto, Ontario, Canada
Michael Todd - University of Iowa, Iowa City, Iowa, USA
James Torner - University of Iowa, Iowa City, Iowa, USA
Mervyn D.I Vergouwen - University Medical Center Utrecht, Utrecht, The Netherlands
George K.C Wong - Chinese University of Hong Kong, Hong Kong, People's Republic of China
SAHIT Collaboration
Resource Type: Journal article
Publication Details: World neurosurgery, Vol.79(3-4), pp.418-422
DOI: 10.1016/j.wneu.2013.01.006
PMID: 23295631
NLM abbreviation: World Neurosurg
ISSN: 1878-8750
eISSN: 1878-8769
Publisher: Elsevier Inc
Grant note: Medical Research Council UK Heart and Stroke Foundation of Canada National Institutes of Health Hong Kong Food and Health Bureau Netherlands Thrombosis Foundation Canadian Institutes for Health Research National Institutes of Health and Brain Aneurysm Foundation Brain Aneurysm Foundation Physicians Services Incorporated Foundation Canadian Institutes of Health Research Netherlands Heart Foundation Ontario Ministry of Research and Innovation Cerecyte Coil Trial Hong Kong University Grant Committee Canadian Stroke Network
Language: English
Date published: 03/2013
Academic Unit: Roy J. Carver Department of Biomedical Engineering; Epidemiology; Surgery; Anesthesia; Injury Prevention Research Center; Neurosurgery; Otolaryngology
Record Identifier: 9983995059202771

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