Subcellular interactions between parallel fibre and climbing fibre signals in Purkinje cells predict sensitivity of classical conditioning to interstimulus interval

Jeanette Hellgren Kotaleski; D. Lester; K. T. Blackwell

doi:10.1007/BF02734249

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Subcellular interactions between parallel fibre and climbing fibre signals in Purkinje cells predict sensitivity of classical conditioning to interstimulus interval

Journal article

Peer reviewed

Subcellular interactions between parallel fibre and climbing fibre signals in Purkinje cells predict sensitivity of classical conditioning to interstimulus interval

Jeanette Hellgren Kotaleski, D. Lester and K. T. Blackwell

Integrative physiological and behavioral science, Vol.37(4), pp.265-292

10/01/2002

DOI: 10.1007/BF02734249

PMID: 12645844

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Abstract

Classical conditioning of the nictitating membrane response requires a specific temporal interval between conditioned stimulus and unconditioned stimulus, and produces an increase in Protein Kinase C (PKC) activation in Purkinje cells. To evaluate whether biochemical interactions within the Purkinje cell may explain the temporal sensitivity, a model of PKC activation by Ca2+, diacylglycerol (DAG), and arachidonic acid (AA) is developed. Ca2+ elevation is due to CF stimulation and IP3 induced Ca2+ release (IICR). DAG and IP3 result from PF stimulation, while AA results from phospholipase A2 (PLA(2)). Simulations predict increased PKC activation when PF stimulation precedes CF stimulation by 0.1 to 3 s. The sensitivity of IICR to the temporal relation between PF and CF stimulation, together with the buffering system of Purkinje cells, significantly contribute to the temporal sensitivity.

Computer Modeling

calcium

classical conditioning

inositol 1,4,5-trisphosphate

IP3 induced calcium release

long-term depression

LTD

membrane

protein kinase C

Purkinje cell

range

Details

Title: Subtitle: Subcellular interactions between parallel fibre and climbing fibre signals in Purkinje cells predict sensitivity of classical conditioning to interstimulus interval
Creators: Jeanette Hellgren Kotaleski - Numerisk analys och datalogi, NADA
D. Lester - KTH Royal Institute of Technology
K. T. Blackwell - KTH Royal Institute of Technology
Resource Type: Journal article
Publication Details: Integrative physiological and behavioral science, Vol.37(4), pp.265-292
DOI: 10.1007/BF02734249
PMID: 12645844
NLM abbreviation: Integr Physiol Behav Sci
ISSN: 1053-881X
eISSN: 2168-7846
Language: English
Date published: 10/01/2002
Academic Unit: Roy J. Carver Department of Biomedical Engineering; Iowa Neuroscience Institute
Record Identifier: 9984446519102771

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