Subchondral bone attrition may be a reflection of compartment-specific mechanical load: the MOST Study

Tuhina Neogi; Michael Nevitt; Jingbo Niu; Leena Sharma; Frank Roemer; Ali Guermazi; Cora E Lewis; James Torner; Kassim Javaid; David Felson

doi:10.1136/ard.2009.110114

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Subchondral bone attrition may be a reflection of compartment-specific mechanical load: the MOST Study

Journal article

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Subchondral bone attrition may be a reflection of compartment-specific mechanical load: the MOST Study

Tuhina Neogi, Michael Nevitt, Jingbo Niu, Leena Sharma, Frank Roemer, Ali Guermazi, Cora E Lewis, James Torner, Kassim Javaid and David Felson

Annals of the rheumatic diseases, Vol.69(5), pp.841-844

05/2010

DOI: 10.1136/ard.2009.110114

PMCID: PMC2891513

PMID: 19762366

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https://www.ncbi.nlm.nih.gov/pmc/articles/2891513View

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Abstract

Subchondral bone attrition (SBA), a feature of osteoarthritis, may be caused by excess focal load to bone, and/or inadequate bone quality to withstand loads through the joint. This study evaluated the effects of malalignment, which can cause focal excessive load, and systemic bone density on the presence and incidence of SBA. The Multicenter Osteoarthritis Study is a cohort of individuals who have or are at high risk of knee osteoarthritis. Baseline alignment and bone mineral density (BMD) measures were assessed. Baseline and 30-month knee magnetic resonance images were graded for SBA (grade 0-3) using the whole-organ magnetic resonance imaging score. The study evaluated the association of alignment in medial and lateral compartments, respectively, and systemic BMD with baseline presence of SBA and incident SBA using logistic regression and adjusting for age, sex and body mass index. Of 1253 participants (mean age 62 years, mean BMI 30, 61% women), 33% had baseline SBA and 44% had knee osteoarthritis. Associations between the presence and incidence of SBA with malalignment in both compartments were noted (odds ratios (95% CI) 2.9 (2.1 to 4.0) and 1.9 (1.2 to 2.9), respectively, for varus knees in the medial compartment; 4.5 (2.8 to 7.1) and 2.1 (1.1 to 4.1), respectively, for valgus knees in the lateral compartment). Low BMD was not associated with SBA. The presence and incidence of SBA are associated with malalignment in a compartment-specific manner, but not with low BMD. SBA may be a marker of increased load experienced by overlying cartilage, which may contribute to increased forces transmitted to the cartilage due to alteration in subchondral bone.

Radiography

Bone Resorption - etiology

Bone Resorption - physiopathology

Bone Density - physiology

Humans

Knee Joint - physiopathology

Middle Aged

Knee Joint - diagnostic imaging

Magnetic Resonance Imaging - methods

Stress, Mechanical

Male

Osteoarthritis, Knee - diagnostic imaging

Weight-Bearing - physiology

Bone Resorption - diagnostic imaging

Osteoarthritis, Knee - complications

Female

Aged

Osteoarthritis, Knee - physiopathology

Details

Title: Subtitle: Subchondral bone attrition may be a reflection of compartment-specific mechanical load: the MOST Study
Creators: Tuhina Neogi - Boston University School of Medicine, 650 Albany Street, Clinical Epidemiology Unit, Suite X-200, Boston, MA 02118, USA. tneogi@bu.edu
Michael Nevitt
Jingbo Niu
Leena Sharma
Frank Roemer
Ali Guermazi
Cora E Lewis
James Torner
Kassim Javaid - University of California, San Francisco
David Felson
Resource Type: Journal article
Publication Details: Annals of the rheumatic diseases, Vol.69(5), pp.841-844
DOI: 10.1136/ard.2009.110114
PMID: 19762366
PMCID: PMC2891513
NLM abbreviation: Ann Rheum Dis
ISSN: 0003-4967
eISSN: 1468-2060
Publisher: England
Grant note: U01 AG018947 / NIA NIH HHS U01 AG018832 / NIA NIH HHS U01 AG18947 / NIA NIH HHS U01 AG18832 / NIA NIH HHS U01 AG019069 / NIA NIH HHS R01 AR048748 / NIAMS NIH HHS U01 AG18820 / NIA NIH HHS AR47885 / NIAMS NIH HHS P60 AR047785 / NIAMS NIH HHS R01 HD043502 / NICHD NIH HHS K23 AR055127 / NIAMS NIH HHS K23 AR055127-03 / NIAMS NIH HHS R01 HD43502 / NICHD NIH HHS U01 AG018820-10 / NIA NIH HHS U01 AG19069 / NIA NIH HHS U01 AG018820 / NIA NIH HHS
Language: English
Date published: 05/2010
Academic Unit: Epidemiology; Surgery; Injury Prevention Research Center; Neurosurgery
Record Identifier: 9983995023002771

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