Subchronic inhalation exposure study of an airborne polychlorinated biphenyl mixture resembling the Chicago ambient air congener profile

Xin Hu; Andrea Adamcakova-Dodd; Hans-Joachim Lehmler; Dingfei Hu; Keri Hornbuckle; Peter S Thorne

doi:10.1021/es301129h

Back

Journal article

Open access

Peer reviewed

Subchronic inhalation exposure study of an airborne polychlorinated biphenyl mixture resembling the Chicago ambient air congener profile

Xin Hu, Andrea Adamcakova-Dodd, Hans-Joachim Lehmler, Dingfei Hu, Keri Hornbuckle and Peter S Thorne

Environmental science & technology, Vol.46(17), pp.9653-9662

09/04/2012

DOI: 10.1021/es301129h

PMCID: PMC3573703

PMID: 22846166

Files and links (1)

url

https://www.ncbi.nlm.nih.gov/pmc/articles/3573703View

Open Access

Abstract

Although inhalation of atmospheric polychlorinated biphenyls (PCBs) is the most universal exposure route and has become a substantial concern in urban areas, research is lacking to determine the body burden of inhaled PCBs and consequent health effects. To reflect the Chicago airshed environment and mimic the PCB profile in Chicago air, we generated vapors from a Chicago air mixture (CAM). Sprague-Dawley rats were exposed to the CAM vapor for 1.6 h/day via nose-only inhalation for 4 weeks, 520 ± 10 μg/m(3). Congener-specific quantification in tissue and air samples was performed by gas chromatography-tandem mass spectrometry (GC/MS/MS). In contrast to the lower-chlorinated congener-enriched vapor, body tissues mainly contained tri- to hexachlorobiphenyls. Congener profiles varied between vapor and tissues and among different organs. The toxic equivalence (TEQ) and neurotoxic equivalence (NEQ) were also investigated for tissue distribution. We evaluated a variety of end points to catalogue the effects of long-term inhalation exposure, including immune responses, enzyme induction, cellular toxicity, and histopathologic abnormalities. Glutathione oxidized/reduced ratio (GSSG/GSH) was increased in the blood of exposed animals, accompanied by elevation of hematocrit. This study demonstrated that inhalation contributed to the body burden of mostly tri- to hexachlorobiphenyls and produced a distinct profile of congeners in tissue, yet minimal toxicity was found at this exposure dose, estimated at 134 μg/rat.

Air Pollutants - metabolism

Animals

Polychlorinated Biphenyls - toxicity

Chicago

Inhalation Exposure

Rats

Female

Polychlorinated Biphenyls - metabolism

Air Pollutants - toxicity

Rats, Sprague-Dawley

Glutathione - blood

Details

Title: Subtitle: Subchronic inhalation exposure study of an airborne polychlorinated biphenyl mixture resembling the Chicago ambient air congener profile
Creators: Xin Hu - Interdisciplinary Graduate Program in Human Toxicology, University of Iowa, Iowa City, Iowa 52242, United States
Andrea Adamcakova-Dodd
Hans-Joachim Lehmler
Dingfei Hu
Keri Hornbuckle
Peter S Thorne
Resource Type: Journal article
Publication Details: Environmental science & technology, Vol.46(17), pp.9653-9662
DOI: 10.1021/es301129h
PMID: 22846166
PMCID: PMC3573703
NLM abbreviation: Environ Sci Technol
ISSN: 1520-5851
eISSN: 1520-5851
Publisher: United States
Grant note: P42 ES013661 / NIEHS NIH HHS P30 ES005605 / NIEHS NIH HHS
Language: English
Date published: 09/04/2012
Academic Unit: Civil and Environmental Engineering; Occupational and Environmental Health; Stead Family Department of Pediatrics; Iowa Neuroscience Institute; Iowa Superfund Research Program
Record Identifier: 9983805905402771

Metrics

21 Record Views

32 Times Cited - Web of Science