Journal article
Subclinical Atherosclerosis, Airflow Obstruction and Emphysema: the MESA Lung Study
The European respiratory journal, Vol.39(4), pp.846-854
04/2012
DOI: 10.1183/09031936.00165410
PMCID: PMC3616898
PMID: 22034646
Abstract
Airflow obstruction is independent risk factor for cardiovascular events in the general population. The affected vascular bed and contribution of emphysema to cardiovascular risk are unclear. We examined if an obstructive pattern of spirometry and quantitatively defined emphysema were associated with subclinical atherosclerosis in the carotid, peripheral and coronary circulations.
The Multi-Ethnic Study of Atherosclerosis recruited participants age 45–84 years without clinical cardiovascular disease. Spirometry, carotid intima-media thickness, ankle-brachial index and coronary artery calcium were measured using standard protocols. Percent of emphysema-like lung was measured in the lung windows of cardiac computed tomography scans among 3,642 participants. Multiple linear regression was used to adjust for cardiac risk factors including C-reactive protein.
Decrements in the FEV
1
and FEV
1
/FVC were associated with greater internal carotid intima-media thickness among smokers (P=0.03 and P<0.001, respectively) whereas percent emphysema was associated with reduced ankle-brachial index regardless of smoking history (P=0.004). Coronary artery calcium was associated with neither lung function (prevalence ratio for severe airflow obstruction: 0.99; 95% CI, 0.91 to 1.07) nor percent emphysema.
An obstructive pattern of spirometry and emphysema are associated distinctly and independently with subclinical atherosclerosis in the carotid arteries and peripheral circulation, respectively, and were not independently related to coronary artery calcium.
Details
- Title: Subtitle
- Subclinical Atherosclerosis, Airflow Obstruction and Emphysema: the MESA Lung Study
- Creators
- R Graham Barr - Department of Medicine, College of Physicians and Surgeons, Columbia University, New York, NYFiras S Ahmed - Department of Medicine, College of Physicians and Surgeons, Columbia University, New York, NYJ Jeffery Carr - Department of Radiology, Wake Forest University, Winston-Salem, NCEric A Hoffman - Department of Radiology, University of Iowa, Iowa City, IARui Jiang - Department of Medicine, College of Physicians and Surgeons, Columbia University, New York, NYSteven M Kawut - Department of Medicine, University of Pennsylvania School of Medicine, and Department of Epidemiology, Center for Clinical Epidemiology and Biostatistics, University of Pennsylvania, Philadelphia, PAKarol Watson - Department of Medicine, University of California, Los Angeles, Los Angeles, CA
- Resource Type
- Journal article
- Publication Details
- The European respiratory journal, Vol.39(4), pp.846-854
- DOI
- 10.1183/09031936.00165410
- PMID
- 22034646
- PMCID
- PMC3616898
- ISSN
- 0903-1936
- eISSN
- 1399-3003
- Grant note
- R01 HL075476 || HL / National Heart, Lung, and Blood Institute : NHLBI R01 HL077612 || HL / National Heart, Lung, and Blood Institute : NHLBI R01 HL093081 || HL / National Heart, Lung, and Blood Institute : NHLBI
- Language
- English
- Date published
- 04/2012
- Academic Unit
- Roy J. Carver Department of Biomedical Engineering; Radiology; Internal Medicine
- Record Identifier
- 9984051753902771
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