Journal article
Subclinical Hypothyroidism and Risk for Incident Ischemic Stroke Among Postmenopausal Women
Thyroid (New York, N.Y.), Vol.24(8), pp.121-1217
08/01/2014
DOI: 10.1089/thy.2014.0106
PMCID: PMC4106389
PMID: 24827923
Abstract
Background:
Subclinical hypothyroidism (SCH) is postulated to increase stroke risk via atherogenic changes associated with abnormal thyroid function. However, the direct relationship of SCH with subsequent stroke is poorly studied.
Methods:
In this nested case–cohort study, we prospectively evaluated the association between any SCH and severity of SCH in relation to incident ischemic stroke risk among postmenopausal women in the Women's Health Initiative Observational Study. Trained Women's Health Initiative staff, masked to thyroid status, adjudicated stroke cases. We assessed thyroid function using baseline blood specimens. Women with normal free thyroxine levels and thyrotropin (TSH) levels ≥4.69 mU/L were considered to have SCH. Primary analysis included 639 ischemic stroke cases and 2927 randomly selected subcohort members with an average of seven years of follow-up.
Results:
The multivariable adjusted hazard ratios (HR) from weighted Cox models were 1.06 (95% confidence interval [CI]: 0.77, 1.46) and 0.99 (95% CI: 0.67, 1.47) for women with any SCH and with mild SCH (TSH 4.69 to 6.99 mU/L), when compared with women with normal thyroid function. The HR for moderate/severe SCH (TSH ≥7.00 mU/L) was modestly elevated (HR: 1.22; 95% CI: 0.73, 2.05).
Conclusions:
We found no evidence to suggest an association between SCH and ischemic stroke among healthy postmenopausal women.
Details
- Title: Subtitle
- Subclinical Hypothyroidism and Risk for Incident Ischemic Stroke Among Postmenopausal Women
- Creators
- Ayush Giri - 1Institute for Medicine and Public Health, Vanderbilt Epidemiology Center, Vanderbilt University, Nashville, TennesseeTodd L Edwards - 1Institute for Medicine and Public Health, Vanderbilt Epidemiology Center, Vanderbilt University, Nashville, TennesseeVicky A LeGrys - 2Division of Clinical Laboratory Science, School of Medicine, University of North Carolina, Chapel Hill, North CarolinaCarol E Lorenz - 3Department of Epidemiology, Center for Women's Health Research, University of North Carolina, Chapel Hill, North CarolinaMichele Jonsson Funk - 4Gillings School of Global Public Health, University of North Carolina, Chapel Hill, North CarolinaRobin Schectman - 5Cecil G. Sheps Center for Health Services Research, University of North Carolina, Chapel Hill, North CarolinaGerardo Heiss - 4Gillings School of Global Public Health, University of North Carolina, Chapel Hill, North CarolinaJennifer G Robinson - 6Departments of Epidemiology and Medicine, College of Public Health, University of Iowa, Iowa City, IowaKatherine E Hartmann - 7Department of Obstetrics and Gynecology, Vanderbilt University Medical School, Nashville, Tennessee
- Resource Type
- Journal article
- Publication Details
- Thyroid (New York, N.Y.), Vol.24(8), pp.121-1217
- DOI
- 10.1089/thy.2014.0106
- PMID
- 24827923
- PMCID
- PMC4106389
- NLM abbreviation
- Thyroid
- ISSN
- 1050-7256
- eISSN
- 1557-9077
- Publisher
- Mary Ann Liebert, Inc
- Language
- English
- Date published
- 08/01/2014
- Academic Unit
- Epidemiology; Internal Medicine
- Record Identifier
- 9983995114702771
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