Journal article
Subcortical and temporal structures in affective disorder and schizophrenia: A magnetic resonance imaging study
Biological psychiatry (1969), Vol.31(3), pp.221-240
1992
DOI: 10.1016/0006-3223(92)90046-3
PMID: 1547297
Abstract
Volumetric measurements of subcortical and temporal structures were done on a sample of 54 schizophrenic patients, who were compared with 48 bipolar patients and 47 normal controls. We observed the male schizophrenic patients to have significant enlargement in the putamen and lesser enlargement in the caudate. We found the righ temporal lobe to be larger than the left across all diagnostic groups, although bipolar females failed to have this asymmetry. We did not replicate the finding of decreased hippocampal, amygdala, or temporal lobe volume in our schizophrenic patients. Nor did we find significant differences between or bipolar patients and controls in the structures measured, with the exception of the right hippocampus. Our findings are consistent with a developmental defect in pruning of subcortical brain regions or with a compensatroy synaptic increase secondary to decreased input from other brain regions such as the prefrontal cortex or anterior temporal lobe structures. Coupled with the lack of temporal lobe asymmetry in bipolar females, these findings suggest that different types of genderspecific neurodevelopmental abnormalities may occur in affective versus schizophrenic psychosis, which may reflect the effects of hormonal influences on brain development in predisposed individuals.
Details
- Title: Subtitle
- Subcortical and temporal structures in affective disorder and schizophrenia: A magnetic resonance imaging study
- Creators
- Victor W Swayze - Psychiatry Service, The University of Iowa Hospitals and Clinics Iowa City, Iowa, USANancy C Andreasen - Veterans Affairs Medical Center, The Mental Helth Clinical Research Center The University of Iowa Hospitals and Clinics Iowa City, Iowa, USARandall J Alliger - Veterans Affairs Medical Center, The Mental Helth Clinical Research Center The University of Iowa Hospitals and Clinics Iowa City, Iowa, USAWilliam T.C Yuh - Department of Radiology, The University of Iowa Hospitals and Clinics Iowa City, Iowa, USAJames C Ehrhardt - Department of Radiology, The University of Iowa Hospitals and Clinics Iowa City, Iowa, USA
- Resource Type
- Journal article
- Publication Details
- Biological psychiatry (1969), Vol.31(3), pp.221-240
- Publisher
- Elsevier Inc
- DOI
- 10.1016/0006-3223(92)90046-3
- PMID
- 1547297
- ISSN
- 0006-3223
- eISSN
- 1873-2402
- Language
- English
- Date published
- 1992
- Academic Unit
- Radiology; Psychiatry; Iowa Neuroscience Institute
- Record Identifier
- 9984003988802771
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