Subcortical hyperintensities impact cognitive function among a select subset of healthy elderly

Robert H PAUL; Omar HAQUE; Kristin L MACGREGOR; Evian GORDON; John GUNSTAD; David F TATE; Stuart M GRIEVE; Karin HOTH; Adam M BRICKMAN; Ronald COHEN; Kelly LANGE; Angela L JEFFERSON

doi:10.1016/j.acn.2005.02.004

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Subcortical hyperintensities impact cognitive function among a select subset of healthy elderly

Journal article

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Subcortical hyperintensities impact cognitive function among a select subset of healthy elderly

Robert H PAUL, Omar HAQUE, Kristin L MACGREGOR, Evian GORDON, John GUNSTAD, David F TATE, Stuart M GRIEVE, Karin HOTH, Adam M BRICKMAN, Ronald COHEN, …

Archives of clinical neuropsychology, Vol.20(6), pp.697-704

2005

DOI: 10.1016/j.acn.2005.02.004

PMCID: PMC2733246

PMID: 15941646

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Abstract

Previous studies have examined the impact of subcortical hyperintensities (SH), a proxy measure of cerebrovascular disease, on the cognitive abilities of otherwise healthy older adults. However, there remains a limited understanding as to what extent this MRI marker of pathological processes explains the decline in specific cognitive functions that occur nearly ubiquitously with advanced age, especially in relation to other age-related imaging markers. In the present study we compared cognitive abilities between a sample of 53 older healthy adults (age range=50-79) and a sample of 53 younger adults (age range=21-40). As expected, the older group performed significantly worse on most cognitive measures compared to the younger group. Frontal volume and total grey matter volume were also significantly reduced among the older individuals compared to the younger individuals. SH volume was consistently associated with cognitive function in older adults, though, this relationship was evident only for a relatively small subset of older individuals with the most severe SH. These data suggest that the relationship between SH and cognition in the elderly is driven by a subset of individuals who may be in the earliest stages of vascular cognitive impairment. Further, the findings suggest that cognitive aging is largely determined by factors other than SH for most older adults.

Neurology

Geriatrics

Organic mental disorders. Neuropsychology

Psychology. Psychoanalysis. Psychiatry

Adult and adolescent clinical studies

Psychopathology. Psychiatry

Biological and medical sciences

Vascular diseases and vascular malformations of the nervous system

Medical sciences

Details

Title: Subtitle: Subcortical hyperintensities impact cognitive function among a select subset of healthy elderly
Creators: Robert H PAUL - Brown Medical School, Centers for Behavioral and Preventive Medicine, Department of Psychiatry and Human Behavior, 1 Hoppin Street, Providence, RI 02903, United States
Omar HAQUE - Brown Medical School, Centers for Behavioral and Preventive Medicine, Department of Psychiatry and Human Behavior, 1 Hoppin Street, Providence, RI 02903, United States
Kristin L MACGREGOR - Brown Medical School, Centers for Behavioral and Preventive Medicine, Department of Psychiatry and Human Behavior, 1 Hoppin Street, Providence, RI 02903, United States
Evian GORDON - Brown Medical School, Centers for Behavioral and Preventive Medicine, Department of Psychiatry and Human Behavior, 1 Hoppin Street, Providence, RI 02903, United States
John GUNSTAD - Brown Medical School, Centers for Behavioral and Preventive Medicine, Department of Psychiatry and Human Behavior, 1 Hoppin Street, Providence, RI 02903, United States
David F TATE - Brown Medical School, Centers for Behavioral and Preventive Medicine, Department of Psychiatry and Human Behavior, 1 Hoppin Street, Providence, RI 02903, United States
Stuart M GRIEVE - Brown Medical School, Centers for Behavioral and Preventive Medicine, Department of Psychiatry and Human Behavior, 1 Hoppin Street, Providence, RI 02903, United States
Karin HOTH - Brown Medical School, Centers for Behavioral and Preventive Medicine, Department of Psychiatry and Human Behavior, 1 Hoppin Street, Providence, RI 02903, United States
Adam M BRICKMAN - Brown Medical School, Centers for Behavioral and Preventive Medicine, Department of Psychiatry and Human Behavior, 1 Hoppin Street, Providence, RI 02903, United States
Ronald COHEN - Brown Medical School, Centers for Behavioral and Preventive Medicine, Department of Psychiatry and Human Behavior, 1 Hoppin Street, Providence, RI 02903, United States
Kelly LANGE - Brown Medical School, Centers for Behavioral and Preventive Medicine, Department of Psychiatry and Human Behavior, 1 Hoppin Street, Providence, RI 02903, United States
Angela L JEFFERSON - Brown Medical School, Centers for Behavioral and Preventive Medicine, Department of Psychiatry and Human Behavior, 1 Hoppin Street, Providence, RI 02903, United States
Resource Type: Journal article
Publication Details: Archives of clinical neuropsychology, Vol.20(6), pp.697-704
Publisher: Elsevier; Amsterdam
DOI: 10.1016/j.acn.2005.02.004
PMID: 15941646
PMCID: PMC2733246
ISSN: 0887-6177
eISSN: 1873-5843
Language: English
Date published: 2005
Academic Unit: Psychiatry; Iowa Neuroscience Institute
Record Identifier: 9984066131302771

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