Journal article
Subcortical volumes across the lifespan: Data from 18,605 healthy individuals aged 3–90 years
Human brain mapping, Vol.43(1), pp.452-469
02/11/2021
DOI: 10.1002/hbm.25320
PMCID: PMC8675429
PMID: 33570244
Abstract
Age has a major effect on brain volume. However, the normative studies available are constrained by small sample sizes, restricted age coverage and significant methodological variability. These limitations introduce inconsistencies and may obscure or distort the lifespan trajectories of brain morphometry. In response, we capitalized on the resources of the Enhancing Neuroimaging Genetics through Meta-Analysis (ENIGMA) Consortium to examine age-related trajectories inferred from cross-sectional measures of the ventricles, the basal ganglia (caudate, putamen, pallidum, and nucleus accumbens), the thalamus, hippocampus and amygdala using magnetic resonance imaging data obtained from 18,605 individuals aged 3-90 years. All subcortical structure volumes were at their maximum value early in life. The volume of the basal ganglia showed a monotonic negative association with age thereafter; there was no significant association between age and the volumes of the thalamus, amygdala and the hippocampus (with some degree of decline in thalamus) until the sixth decade of life after which they also showed a steep negative association with age. The lateral ventricles showed continuous enlargement throughout the lifespan. Age was positively associated with inter-individual variability in the hippocampus and amygdala and the lateral ventricles. These results were robust to potential confounders and could be used to examine the functional significance of deviations from typical age-related morphometric patterns.
Details
- Title: Subtitle
- Subcortical volumes across the lifespan: Data from 18,605 healthy individuals aged 3–90 years
- Creators
- Danai DimaAmirhossein ModabberniaEfstathios PapachristouGaelle E DoucetIngrid AgartzMoji AghajaniTheophilus N AkudjeduAnton Albajes EizagirreDag AlnæsKathryn I AlpertMicael AnderssonAnders M DaleDan J SteinLachlan T StrikeSarah BaumeisterSuzanne C SwagermanSarah HohmannBarbara FrankeLara M WierengaLaura KoendersXavier CaserasSalvador SarróHeather WhalleyChristian K TamnesDerrek P HibarDennis MeerChristopher DaveyNic J. A WeeNeeltje E. M HarenDennis EntDara M CannonTheo G. M ErpBen J HarrisonLieuwe HaanDorret I BoomsmaIlya M VeerAlexander S TomyshevAlessandro BertolinoEsther WaltonTatyana P KlyushnikSteven C. R WilliamsPaola Fuentes ClaramonteKatharina WittfeldCatharine A HartmanDaniel H WolfAmanda WorkerJonna KuntsiMargaret J WrightErik G JönssonFrancisco X CastellanosHans Jörgen GrabeKun YangThomas H WassinkSophia FrangouSean N HattonStefan BorgwardtJosiane BourquePieter J HoekstraDaniel BrandeisAlan BreierJohn A JoskaHenry BrodatyIan H GotlibRachel M BrouwerJan K BuitelaarAndreas HeinzBernard MazoyerMartine HoogmanGreig I ZubicaraySanne KoopsPhilip AshersonSimon CervenkaRene KahnTiffany M Chaim AvanciniChristopher R. K ChingBernd KrämerPaul PauliVictoria ChubarVincent P ClarkColm McdonaldPatricia ConrodAvram J HolmesAnnette ConzelmannOliver GrimmAndrew KalninJaap OosterlaanLuisa LázaroSophia I ThomopoulosBenedicto Crespo FacorroKarolinska Schizophrenia ProjectRaymond SalvadorAnouk BraberBrenna C McdonaldErin W DickieAnnabella Di GiorgioNhat Trung DoanAndrew J SaykinErlend S DørumWon Hee LeeStefan EhrlichVíctor Ortiz‐García FozSusanne ErkThomas EspesethJim LagopoulosHelena Fatouros BergmanAndrew M McintoshPascual Sánchez JuanFleur M HowellsYang WangOle A AndreassenNorbert HostenSimon E FisherHenk S TemminghNynke A GroenewoldYannis PaloyelisDominik GrotegerdOliver GruberPatricia GrunerJulian N TrollorRachel E GurGiulio PergolaKlaus Peter LeschRuben C GurThomas FrodlIrina LebedevaDirk J HeslenfeldLei WangHilleke E Hulshoff PolTheodore D SatterthwaiteChaim HuyserNeda JahanshadAnthony JamesWei WenTerry L JerniganDick J VeltmanMauricio H SerpaKatie L McmahonJiyang JiangBeng Choon HoRyota KanaiMarieke KleinNancy C AndreasenChristine LochnerDiana Tordesillas GutiérrezMarise W. J MachielsenAristotle VoineskosSophie MaingaultNicholas G MartinNuria BargalloIgnacio Martínez ZalacaínYulyia YonchevaAnne UhlmannEdith Pomarol ClotetDavid Mataix ColsGeraldo F BusattoGenevieve McphilemyHenry VölzkeJosé Manuel Menchón MagriñáSarah E MedlandAndreas Meyer LindenbergBernd WeberJilly NaaijenMarcus V ZanettiPablo NajtTomohiro NakaoJessica A TurnerJan E NordvikHenrik WalterRandy L BucknerLars T WestlyeLianne SchmaalLars NybergFabrice CrivelloMaria J PortellaGeorg C ZieglerSteven G PotkinJoaquim RaduaAndreas ReifEco J. C GeusTobias BanaschewskiDaniel A RinkerVincent CalhounJoshua L RoffmanPedro G. P RosaJohn D WestMatthew D SacchetPaul M ThompsonEveline A CroneRamona Baur StreubelIan B HickieOdile A HeuvelPerminder S SachdevJean Paul FoucheKnut SchnellErick J Canales RodríguezGunter SchumannKang SimJordan W SmollerDavid C GlahnIris SommerAurora BonvinoCarles Soriano‐mas
- Resource Type
- Journal article
- Publication Details
- Human brain mapping, Vol.43(1), pp.452-469
- DOI
- 10.1002/hbm.25320
- PMID
- 33570244
- PMCID
- PMC8675429
- NLM abbreviation
- Hum Brain Mapp
- ISSN
- 1065-9471
- eISSN
- 1097-0193
- Publisher
- Wiley
- Grant note
- DOI: 10.13039/100000025, name: National Institute of Mental Health, award: MH104284, MH116147, R01MH113619, R01 MH090553, R01MH117014, R01MH042191; DOI: 10.13039/501100004047, name: Karolinska Institutet; DOI: 10.13039/501100004348, name: Stockholms Läns Landsting; DOI: 10.13039/501100006095, name: Helse Sør-Øst RHF; DOI: 10.13039/100010447, name: Deutsches Zentrum für Herz-Kreislaufforschung; DOI: 10.13039/100010447, name: Deutsches Zentrum für Herz-Kreislaufforschung; DOI: 10.13039/501100011699, name: Siemens Healthineers; DOI: 10.13039/501100001794, name: University of Queensland; DOI: 10.13039/100009633, name: Eunice Kennedy Shriver National Institute of Child Health and Human Development; DOI: 10.13039/100000026, name: National Institute on Drug Abuse, award: UL1 TR000153, 1 U24 RR025736‐01, 1 U24 RR021992; DOI: 10.13039/100012700, name: Parents Against Childhood Epilepsy; DOI: 10.13039/100010170, name: Epilepsy Foundation of Victoria; DOI: 10.13039/100001454, name: American Epilepsy Society; DOI: 10.13039/501100004063, name: Knut och Alice Wallenbergs Stiftelse; DOI: 10.13039/501100008358, name: Hersenstichting; DOI: 10.13039/501100001829, name: Universiteit Utrecht; DOI: 10.13039/100011199, name: FP7 Ideas: European Research Council; DOI: 10.13039/501100003246, name: Nederlandse Organisatie voor Wetenschappelijk Onderzoek; DOI: 10.13039/100006108, name: National Center for Advancing Translational Sciences; DOI: 10.13039/100000002, name: National Institutes of Health; DOI: 10.13039/100000097, name: National Center for Research Resources; DOI: 10.13039/501100007155, name: Medical Research Council Canada, award: G0500092; DOI: 10.13039/501100004587, name: Instituto de Salud Carlos III, award: PI14/00918, PI14/00639, PI060507, PI050427, PI020499; DOI: 10.13039/501100004787, name: The Research Council, award: 223273; DOI: 10.13039/501100004359, name: Vetenskapsrådet; DOI: 10.13039/501100000764, name: King's College London; DOI: 10.13039/100009362, name: South London and Maudsley NHS Foundation Trust; DOI: 10.13039/100014461, name: NIHR Biomedical Research Centre, Royal Marsden NHS Foundation Trust/Institute of Cancer Research; DOI: 10.13039/501100000272, name: National Institute for Health Research
- Language
- English
- Date published
- 02/11/2021
- Academic Unit
- Psychiatry; Stead Family Department of Pediatrics; Iowa Neuroscience Institute
- Record Identifier
- 9984068246002771
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