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Subgenual Cingulate Theta Activity Predicts Treatment Response of Repetitive Transcranial Magnetic Stimulation in Participants With Vascular Depression
Journal article   Peer reviewed

Subgenual Cingulate Theta Activity Predicts Treatment Response of Repetitive Transcranial Magnetic Stimulation in Participants With Vascular Depression

Kenji Narushima, Laurie McCormick, Throu Yamada, Robert Thatcher and Robert G Robinson
The journal of neuropsychiatry and clinical neurosciences, Vol.22(1), pp.75-84
2010
DOI: 10.1176/appi.neuropsych.22.1.75
PMCID: PMC3688059
PMID: 20160213
url
https://www.ncbi.nlm.nih.gov/pmc/articles/3688059View
Open Access

Abstract

Repetitive transcranial magnetic stimulation (rTMS) is an effective treatment for depression. Increased metabolism in the anterior cingulate cortex (ACC) is a known predictor for antidepressant response. The authors assessed whether increased theta power within the ACC predicts rTMS response in participants with vascular depression. Sixty-five participants were randomized to active or sham rTMS. Outcome was assessed using the Hamilton Depression Rating Scale. Electroencephalography was obtained, and comparisons were made among each group with a normative database using low-resolution electromagnetic tomography. Results suggest that vascular depression participants respond well to rTMS and that increased low-theta power in the subgenual ACC predicts response to rTMS.

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