Journal article
Subjective Cognitive Complaints Relate to White Matter Hyperintensities and Future Cognitive Decline in Patients With Cardiovascular Disease
The American journal of geriatric psychiatry, Vol.17(11), pp.976-985
11/2009
DOI: 10.1097/JGP.0b013e3181b208ef
PMCID: PMC2813459
PMID: 20104055
Abstract
Elderly patients with cardiovascular disease (CVD) often report cognitive difficulties including reduced cognitive processing speed and attention. On cross-sectional examination, such reports relate more closely to mood than to objective measures of cognitive performance, thus questioning the validity of subjective cognitive complaints as a marker of neurodegenerative processes. This study examined the longitudinal relationship among self-reported cognitive difficulties, depression, and performance on objective tests of global cognition in patients with CVD.\nForty-seven patients with CVD (aged 55–85 years) completed a measure of perceived cognitive dysfunction (Cognitive Difficulties Scale [CDS]), a medical history questionnaire, the Dementia Rating Scale (DRS), and the Beck Depression Inventory (BDI) at baseline and 12 months later. Baseline brain imaging was available on a small subsample (N = 17).\nHierarchical linear regression revealed that increased report of cognitive difficulties at baseline was significantly associated with poorer DRS performance at follow-up (F[3, 43] = 4.45, p = 0.008, CDS partial r = −0.30, p = 0.048), independent of age, education, baseline DRS, and BDI scores. Greater perceived cognitive dysfunction at baseline also related to higher level of white matter lesions (r = 0.53, df = 15, p = 0.028).\nSelf-reported cognitive difficulties may reflect early changes in cognitive aging that are difficult to detect using global cognitive screening measures at a single time point. However, these perceived difficulties relate to objectively measured cognitive decline over time. Thus, they may provide important clinical information about early neurodegenerative processes that should be carefully monitored.
Details
- Title: Subtitle
- Subjective Cognitive Complaints Relate to White Matter Hyperintensities and Future Cognitive Decline in Patients With Cardiovascular Disease
- Creators
- Andreana P Haley - Department of Psychology, The University of Texas at Austin, Austin, TXKarin F Hoth - National Jewish Medical and Research Center, Denver, COJohn Gunstad - Department of Psychology, Kent State University, Kent, OHRobert H Paul - Department of Behavioral Neuroscience, University of Missouri, St. Louis, MOAngela L Jefferson - Department of Neurology, Alzheimer's Disease Center, Boston University School of Medicine, BostonDavid F Tate - Center for Neurological Imaging, Brigham and Women's Hospital, Harvard Medical School, Boston, MAMakoto Ono - Department of Psychiatry and Human Behavior, Alpert Medical School of Brown University, Providence, RIBeth A Jerskey - Department of Psychiatry and Human Behavior, Alpert Medical School of Brown University, Providence, RIAthena Poppas - Department of Cardiology, Alpert Medical School of Brown University, Providence, RILawrence H Sweet - Department of Psychiatry and Human Behavior, Alpert Medical School of Brown University, Providence, RIRonald A Cohen - Department of Psychiatry and Human Behavior, Alpert Medical School of Brown University, Providence, RI
- Resource Type
- Journal article
- Publication Details
- The American journal of geriatric psychiatry, Vol.17(11), pp.976-985
- DOI
- 10.1097/JGP.0b013e3181b208ef
- PMID
- 20104055
- PMCID
- PMC2813459
- NLM abbreviation
- Am J Geriatr Psychiatry
- ISSN
- 1064-7481
- eISSN
- 1545-7214
- Publisher
- Elsevier Inc
- Grant note
- AG017975 (to RAC), AG020498 (to APH and BAJ), AG026850 (to KFH), HL074568 (to JG), MH065857 and 5R01NS052470 (to RHP), and K23-AG030962 and P30-AG013846 (to ALJ) / National Institute of Health
- Language
- English
- Date published
- 11/2009
- Academic Unit
- Psychiatry; Iowa Neuroscience Institute
- Record Identifier
- 9984066134802771
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