Subjective cognitive complaints and neuropsychological performance in former smokers with and without chronic obstructive pulmonary disease

Amanda M Brunette; Kristen E Holm; Frederick S Wamboldt; Elizabeth Kozora; David J Moser; Barry J Make; James D Crapo; Kimberly Meschede; Howard D Weinberger; Kerrie L Moreau; Russell P Bowler; Karin F Hoth

doi:10.1080/13803395.2017.1356912

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Subjective cognitive complaints and neuropsychological performance in former smokers with and without chronic obstructive pulmonary disease

Journal article

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Subjective cognitive complaints and neuropsychological performance in former smokers with and without chronic obstructive pulmonary disease

Amanda M Brunette, Kristen E Holm, Frederick S Wamboldt, Elizabeth Kozora, David J Moser, Barry J Make, James D Crapo, Kimberly Meschede, Howard D Weinberger, Kerrie L Moreau, …

Journal of clinical and experimental neuropsychology, Vol.40(4), pp.411-422

04/21/2018

DOI: 10.1080/13803395.2017.1356912

PMCID: PMC5953430

PMID: 28766459

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https://www.ncbi.nlm.nih.gov/pmc/articles/5953430View

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Abstract

Objective: This study examined the association of perceived cognitive difficulties with objective cognitive performance in former smokers. We hypothesized that greater perceived cognitive difficulties would be associated with poorer performance on objective executive and memory tasks.\nMethod: Participants were 95 former smokers recruited from the COPDGene study. They completed questionnaires (including the Cognitive Difficulties Scale [CDS] and the Hospital Anxiety and Depression Scale [HADS]), neuropsychological assessment, and pulmonary function testing. Pearson correlations and t-tests were conducted to examine the bivariate association of the CDS (total score and subscales for attention/concentration, praxis, delayed recall, orientation for persons, temporal orientation, and prospective memory) with each domain of objective cognitive functioning (memory recall, executive functioning/processing speed, visuospatial processing, and language). Simultaneous multiple linear regression was used to further examine all statistically significant bivariate associations. The following covariates were included in all regression models: age, sex, pack-years, premorbid functioning (WRAT-IV Reading), HADS total score, and chronic obstructive pulmonary disease (COPD) status (yes/no based on GOLD criteria).\nResults: In regression models, greater perceived cognitive difficulties overall (using CDS total score) were associated with poorer performance on executive functioning/processing speed tasks (b = −0.07, SE = 0.03, p = .037). Greater perceived cognitive difficulties on the CDS praxis subscale were associated with poorer performance on executive functioning/processing speed tasks (b = −3.65, SE = 1.25, p = .005), memory recall tasks (b = −4.60, SE = 1.75, p = .010), and language tasks (b = −3.89, SE = 1.39, p = .006).\nConclusions: Clinicians should be aware that cognitive complaints may be indicative of problems with the executive functioning/processing speed and memory of former smokers with and without COPD.

neuropsychology

Cognition

lung disease

self-report

Cognitive Difficulties Scale

Details

Title: Subtitle: Subjective cognitive complaints and neuropsychological performance in former smokers with and without chronic obstructive pulmonary disease
Creators: Amanda M Brunette - Department of Psychological and Brain Sciences, University of Iowa
Kristen E Holm - Department of Community and Behavioral Health, Colorado School of Public Health
Frederick S Wamboldt - Department of Psychiatry, University of Colorado School of Medicine at the Anschutz Medical Campus
Elizabeth Kozora - Department of Psychiatry, University of Colorado School of Medicine at the Anschutz Medical Campus
David J Moser - Department of Psychiatry, University of Iowa Carver College of Medicine
Barry J Make - Department of Medicine, University of Colorado School of Medicine at the Anschutz Medical Campus
James D Crapo - Department of Medicine, University of Colorado School of Medicine at the Anschutz Medical Campus
Kimberly Meschede - Department of Medicine, National Jewish Health
Howard D Weinberger - Department of Medicine, University of Colorado School of Medicine at the Anschutz Medical Campus
Kerrie L Moreau - Geriatric Research Education and Clinical Center, Denver Veterans Administration Medical Center
Russell P Bowler - Department of Medicine, University of Colorado School of Medicine at the Anschutz Medical Campus
Karin F Hoth - Department of Psychiatry, University of Iowa Carver College of Medicine
Resource Type: Journal article
Publication Details: Journal of clinical and experimental neuropsychology, Vol.40(4), pp.411-422
DOI: 10.1080/13803395.2017.1356912
PMID: 28766459
PMCID: PMC5953430
NLM abbreviation: J Clin Exp Neuropsychol
ISSN: 1380-3395
eISSN: 1744-411X
Publisher: Taylor & Francis Group
Grant note: K23 HL095658; R01 HL089856; R01 HL089897; UL1 TR001082 / National Institutes of Health (10.13039/100000002)\nno specific grant number / COPD Foundation (10.13039/100008184)
Language: English
Date published: 04/21/2018
Academic Unit: Psychiatry; Iowa Neuroscience Institute; Medicine Administration
Record Identifier: 9984066145802771

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