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Sublimation aides and abets co-milling and discoloration involving quinhydrone
Journal article   Open access   Peer reviewed

Sublimation aides and abets co-milling and discoloration involving quinhydrone

Charles Izuchukwu Ezekiel and Leonard R. MacGillivray
Frontiers in chemistry, Vol.14, 1741180
2026
DOI: 10.3389/fchem.2026.1741180
PMID: 41732171
url
https://doi.org/10.3389/fchem.2026.1741180View
Published (Version of record) Open Access

Abstract

We report an application of co-milling to the binary cocrystal (BZQ)·(HQ) or commonly known as quinhydrone. The co-milling is performed with either trans-bis(4-pyridyl)ethylene (4.4′-BPE) or 4-methoxyaniline (4-MA). In both cases, the dark green color of (BZQ)·(HQ) in the sample undergoes discoloration with the co-milling. Sublimation of BZQ occurs with dismantling of (BZQ)·(HQ) to allow for formation of the targeted cocrystals (HQ)·(4,4′-BPE) and (HQ)·2(4-MA).
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