Journal article
Submental negative pressure application decreases collapsibility of the passive pharyngeal airway in nonobese women
Journal of applied physiology (1985), Vol.118(7), pp.912-920
04/01/2015
DOI: 10.1152/japplphysiol.00158.2014
PMID: 25614595
Abstract
The pharyngeal airway is surrounded by soft tissues that are also enclosed by bony structures such as the mandible, maxilla, and cervical spine. The passive pharyngeal airway is therefore structurally analogous to a collapsible tube within a rigid box. Cross-sectional area of the tube is determined by transmural pressure, the pressure difference between intraluminal and extraluminal pressures. Due to a lack of knowledge on the influence of extraluminal soft tissue pressure on the human pharyngeal airway patency, we hypothesized that application of negative external pressure to the submental region decreases collapsibility of the passive pharynx, and that obese individuals have less response to the intervention than nonobese individuals. Static mechanical properties of the passive pharynx were compared before and during application of submental negative pressure in 10 obese and 10 nonobese adult women under general anesthesia and paralysis. Negative pressure was applied through use of a silicone collar covering the entire submental region and a vacuum pump. In nonobese subjects, application of submental negative pressure (-25 and -50 cmH(2)O) significantly decreased closing pressures at the retropalatal airway by 2.3 +/- 3.2 cmH(2)O and 2.0 +/- 3.0 cmH(2)O, respectively, and at the retroglossal airway by 2.9 +/- 2.7 cmH(2)O and 3.7 +/- 2.6 cmH(2)O, respectively, and the intervention stiffened the retroglossal pharyngeal airway wall. No significant mechanical changes were observed during application of submental negative pressure in obese subjects. Conclusively, application of submental negative pressure was found to decreases collapsibility of the passive pharyngeal airway in nonobese Japanese women.
Details
- Title: Subtitle
- Submental negative pressure application decreases collapsibility of the passive pharyngeal airway in nonobese women
- Creators
- Shinichiro Kato - Chiba UniversityShiroh Isono - Chiba UniversityMegumi Amemiya - Chiba UniversityShin Sato - Chiba UniversityAya Ikeda - Chiba UniversityJunko Okazaki - Chiba UniversityYumi Sato - Chiba UniversityTeruhiko Ishikawa - Chiba University
- Resource Type
- Journal article
- Publication Details
- Journal of applied physiology (1985), Vol.118(7), pp.912-920
- DOI
- 10.1152/japplphysiol.00158.2014
- PMID
- 25614595
- NLM abbreviation
- J Appl Physiol (1985)
- ISSN
- 8750-7587
- eISSN
- 1522-1601
- Publisher
- Amer Physiological Soc
- Number of pages
- 9
- Grant note
- 24390363 / Ministry of Education, Culture, Sports, Science and Technology, Tokyo, Japan; Ministry of Education, Culture, Sports, Science and Technology, Japan (MEXT) 24390363 / Grants-in-Aid for Scientific Research; Ministry of Education, Culture, Sports, Science and Technology, Japan (MEXT); Japan Society for the Promotion of Science; Grants-in-Aid for Scientific Research (KAKENHI)
- Language
- English
- Date published
- 04/01/2015
- Academic Unit
- Anesthesia
- Record Identifier
- 9985090616202771
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