Subretinal fibrosis in central serous chorioretinopathy

H Schatz; H R McDonald; R N Johnson; Clement K Chan; A R Irvine; Alan R Berger; J C Folk; D M Robertson

doi:10.1016/s0161-6420(95)30908-6

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Subretinal fibrosis in central serous chorioretinopathy

Journal article

Peer reviewed

Subretinal fibrosis in central serous chorioretinopathy

H Schatz, H R McDonald, R N Johnson, Clement K Chan, A R Irvine, Alan R Berger, J C Folk and D M Robertson

Ophthalmology (Rochester, Minn.), Vol.102(7), pp.1077-1088

07/1995

DOI: 10.1016/s0161-6420(95)30908-6

PMID: 9121756

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Abstract

To report unusual and heretofore unreported visually damaging manifestations of severe central serous chorioretinopathy. Case studies. Each of six male patients (average age, 40 years) had a form of severe central serous chorioretinopathy with at least one eye containing fibrin in the subretinal space that then developed into a subretinal fibrotic scar. Scar formation was followed by a tenting up of the macula, vascularization of the fibrosis (subretinal neovascularization), or a retinal pigment epithelial rip. Four of the seven eyes with subretinal fibrosis had severe visual loss (20/400 or worse). Subretinal fibrin and other extracellular matrix molecules appear to stimulate the retinal pigment epithelium to undergo fibrous metaplasia, which results in subretinal fibrotic scar formation and other sequelae, all of which can lead to severe visual loss.

Retinal Detachment - etiology

Retinal Detachment - pathology

Choroid Diseases - complications

Retinal Diseases - complications

Humans

Middle Aged

Male

Visual Acuity

Fibrin

Choroid Diseases - pathology

Fibrosis - etiology

Retinal Diseases - pathology

Adult

Body Fluids

Fundus Oculi

Retina - pathology

Exudates and Transudates

Fluorescein Angiography

Vision Disorders - etiology

Details

Title: Subtitle: Subretinal fibrosis in central serous chorioretinopathy
Creators: H Schatz - Retina Research Fund, St. Mary's Medical Center, San Francisco, CA, USA
H R McDonald
R N Johnson
Clement K Chan - Loma Linda University
A R Irvine
Alan R Berger - University of Toronto
J C Folk
D M Robertson
Resource Type: Journal article
Publication Details: Ophthalmology (Rochester, Minn.), Vol.102(7), pp.1077-1088
Publisher: United States
DOI: 10.1016/s0161-6420(95)30908-6
PMID: 9121756
ISSN: 0161-6420
eISSN: 1549-4713
Language: English
Date published: 07/1995
Academic Unit: Ophthalmology and Visual Sciences
Record Identifier: 9983980011602771

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