Subretinal pseudocyst: A novel optical coherence tomography finding in age-related macular degeneration

Riccardo Sacconi; Robert F Mullins; Gerard A Lutty; Enrico Borrelli; Francesco Bandello; Giuseppe Querques

doi:10.1177/1120672119846437

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Subretinal pseudocyst: A novel optical coherence tomography finding in age-related macular degeneration

Journal article

Peer reviewed

Subretinal pseudocyst: A novel optical coherence tomography finding in age-related macular degeneration

Riccardo Sacconi, Robert F Mullins, Gerard A Lutty, Enrico Borrelli, Francesco Bandello and Giuseppe Querques

European journal of ophthalmology, Vol.30(3), pp.NP24-NP26

05/2020

DOI: 10.1177/1120672119846437

PMID: 31018677

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Abstract

To report the presence of a new structural optical coherence tomography finding, namely, subretinal pseudocysts, in a patient affected by age-related macular degeneration. Case report including multimodal imaging discussion. We report a case of a 77-year-old woman affected by age-related macular degeneration from 7 years. Best corrected visual acuity was counting fingers and 20/40 in the right and left eye, respectively. The left eye was affected by type 1 macular neovascularization treated by 34 intravitreal injections of anti-vascular endothelial growth factor (22 ranibizumab and 12 aflibercept injections). Interestingly, structural optical coherence tomography showed the persistence of a subretinal cystoid space (i.e. 'subretinal pseudocyst') after the last anti-vascular endothelial growth factor treatment, even in absence of other signs of exudation. Subretinal pseudocysts are a new structural optical coherence tomography entity. We reported for the first time the evidence that pseudocysts may develop in the subretinal space in a case of age-related macular degeneration.

Aged

Angiogenesis Inhibitors - therapeutic use

Choroidal Neovascularization - diagnostic imaging

Choroidal Neovascularization - drug therapy

Female

Fluorescein Angiography - methods

Humans

Intravitreal Injections

Macular Edema - diagnostic imaging

Macular Edema - drug therapy

Multimodal Imaging

Ranibizumab - therapeutic use

Receptors, Vascular Endothelial Growth Factor - therapeutic use

Recombinant Fusion Proteins - therapeutic use

Retrospective Studies

Tomography, Optical Coherence - methods

Vascular Endothelial Growth Factor A - antagonists & inhibitors

Visual Acuity - physiology

Wet Macular Degeneration - diagnostic imaging

Wet Macular Degeneration - drug therapy

Details

Title: Subtitle: Subretinal pseudocyst: A novel optical coherence tomography finding in age-related macular degeneration
Creators: Riccardo Sacconi - Vita-Salute San Raffaele University
Robert F Mullins - University of Iowa
Gerard A Lutty - Johns Hopkins University
Enrico Borrelli - Vita-Salute San Raffaele University
Francesco Bandello - Vita-Salute San Raffaele University
Giuseppe Querques - Vita-Salute San Raffaele University
Resource Type: Journal article
Publication Details: European journal of ophthalmology, Vol.30(3), pp.NP24-NP26
DOI: 10.1177/1120672119846437
PMID: 31018677
ISSN: 1120-6721
eISSN: 1724-6016
Language: English
Date published: 05/2020
Academic Unit: Ophthalmology and Visual Sciences
Record Identifier: 9984182756702771

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