Journal article
Subsecond Multisection CT of Regional Pulmonary Ventilation
Academic radiology, Vol.9(2), pp.130-146
2002
DOI: 10.1016/S1076-6332(03)80163-0
PMID: 11918366
Abstract
To evaluate the adequacy of multibreath and single-breath stable xenon gas techniques to measure regional ventilation during cardiac-gated, high-speed, multisection imaging, the authors carried out a series of studies using electron-beam computed tomography (CT) and a recently introduced subsecond multisection spiral CT scanner.
In four anesthetized pigs, the authors implemented single-breath and/or dynamic multibreath wash-in and washout protocols with respiratory- and cardiac-gated image acquisition. The effects of varying tidal volume and inspiratory flow rate were evaluated independently. Scanning was done at end expiration to avoid artifacts from partial volumed conducting airways, which are filled with inspired gas concentration during inspiration.
A single breath of 100% xenon provides adequate enhancement in the lung parenchyma (mean, 32 HU ± 1.85 [standard error]) and should not cause unwanted side effects (mean xenon concentration in lung periphery, 21%). The single-breath method is suitable for studies requiring only short periods of apnea. Using the multibreath method, in dependent portions of the lung, there was close agreement between measured changes and predictions based on the xenon calibration data. More than 10 breaths were needed to clear tracer from poorly ventilated areas, and some nondependent regions demonstrated apparently “linear” rather than exponential clearance curves, possibly reflecting longer washout times. Analysis of wash-in and washout curves revealed vertical ventilation gradients and, at higher inspiratory flow rates, redistribution of ventilation to areas of the lung with greater pathway conductance.
With careful attention to lung volume and use of cardiac gating, it is now possible to correlate lung structure with function to a degree heretofore not possible.
Details
- Title: Subtitle
- Subsecond Multisection CT of Regional Pulmonary Ventilation
- Creators
- Jehangir K Tajik - Department of Physiology, University of Iowa College of Medicine, 200 Hawkins Dr, Iowa City, IA 52242, USADeokiee Chon - Department of Biomedical Engineering, University of Iowa College of Medicine, 200 Hawkins Dr, Iowa City, IA 52242, USAChulho Won - Department of Radiology, University of Iowa College of Medicine, 200 Hawkins Dr, Iowa City, IA 52242, USABinh Q Tran - Department of Biomedical Engineering, University of Iowa College of Medicine, 200 Hawkins Dr, Iowa City, IA 52242, USAEric A Hoffman - Department of Physiology, University of Iowa College of Medicine, 200 Hawkins Dr, Iowa City, IA 52242, USA
- Resource Type
- Journal article
- Publication Details
- Academic radiology, Vol.9(2), pp.130-146
- Publisher
- Elsevier Inc
- DOI
- 10.1016/S1076-6332(03)80163-0
- PMID
- 11918366
- ISSN
- 1076-6332
- eISSN
- 1878-4046
- Language
- English
- Date published
- 2002
- Academic Unit
- Roy J. Carver Department of Biomedical Engineering; Radiology; Internal Medicine
- Record Identifier
- 9984051994402771
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