Substance use in persons with schizophrenia: baseline prevalence and correlates from the NIMH CATIE study

Marvin S Swartz; H Ryan Wagner; Jeffrey W Swanson; T Scott Stroup; Joseph P McEvoy; Jose M Canive; Del D Miller; Fred Reimherr; Mark McGee; Ahsan Khan; Richard Van Dorn; Robert A Rosenheck; Jeffrey A Lieberman

doi:10.1097/01.nmd.0000202575.79453.6e

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Substance use in persons with schizophrenia: baseline prevalence and correlates from the NIMH CATIE study

Journal article

Peer reviewed

Substance use in persons with schizophrenia: baseline prevalence and correlates from the NIMH CATIE study

Marvin S Swartz, H Ryan Wagner, Jeffrey W Swanson, T Scott Stroup, Joseph P McEvoy, Jose M Canive, Del D Miller, Fred Reimherr, Mark McGee, Ahsan Khan, …

The journal of nervous and mental disease, Vol.194(3), pp.164-172

03/2006

DOI: 10.1097/01.nmd.0000202575.79453.6e

PMID: 16534433

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Abstract

This study examined baseline correlates of substance use in the NIMH Clinical Antipsychotic Trials of Intervention Effectiveness project. Approximately 60% of the sample was found to use substances, including 37% with current evidence of substance use disorders. Users (with and without substance use disorders), compared with nonusers, were significantly more likely to be male, be African-American, have lower educational attainment, have a recent period of homelessness, report more childhood conduct problems, have a history of major depression, have lower negative symptom and higher positive symptom scores on the Positive and Negative Syndrome Scale, and have a recent illness exacerbation. Individuals with comorbid substance use disorders were significantly more likely to be male, report more childhood conduct problems, have higher positive symptom scores on the Positive and Negative Syndrome Scale, and have a recent illness exacerbation. These analyses suggest that substance use disorders in schizophrenia are especially common among men with a history of childhood conduct disorder problems and that childhood conduct disorder problems are potent risk factors for substance use disorders in schizophrenia.

United States - epidemiology

Conduct Disorder - diagnosis

Prevalence

Randomized Controlled Trials as Topic - methods

Humans

Male

Thiazoles - therapeutic use

Schizophrenic Psychology

Schizophrenia - diagnosis

Antipsychotic Agents - therapeutic use

Substance-Related Disorders - epidemiology

Female

Substance-Related Disorders - diagnosis

Multicenter Studies as Topic - statistics & numerical data

Randomized Controlled Trials as Topic - statistics & numerical data

Cross-Sectional Studies

Double-Blind Method

Comorbidity

Risk Factors

Treatment Outcome

Piperazines - therapeutic use

Schizophrenia - epidemiology

Conduct Disorder - epidemiology

Sex Factors

Schizophrenia - drug therapy

Diagnosis, Dual (Psychiatry)

Details

Title: Subtitle: Substance use in persons with schizophrenia: baseline prevalence and correlates from the NIMH CATIE study
Creators: Marvin S Swartz - Department of Psychiatry and Behavioral Sciences, Duke University School of Medicine, Durham, NC 27710, USA
H Ryan Wagner
Jeffrey W Swanson
T Scott Stroup
Joseph P McEvoy
Jose M Canive
Del D Miller
Fred Reimherr
Mark McGee
Ahsan Khan
Richard Van Dorn
Robert A Rosenheck
Jeffrey A Lieberman
Resource Type: Journal article
Publication Details: The journal of nervous and mental disease, Vol.194(3), pp.164-172
Publisher: United States
DOI: 10.1097/01.nmd.0000202575.79453.6e
PMID: 16534433
ISSN: 0022-3018
eISSN: 1539-736X
Grant note: N01 MH90001 / NIMH NIH HHS
Language: English
Date published: 03/2006
Academic Unit: Psychiatry
Record Identifier: 9984004197502771

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