Substrate recognition and cleavage mechanism of the monkeypox protease, Core protease

The authors thank the Bio-Electron Microscopy Facility of ShanghaiTech University for technical support; the campus service team of ShanghaiTech University, scientific research platform of Shanghai Institute for Advanced Immunochemical Studies (SIAIS) and National Facility for Protein Science in Shanghai, as well as the managers and technicians who provided onsite or remote technical support; and the staff at the BL10U2 at Shanghai Synchrotron Radiation Facility (SSRF, China), where data were collected. This work was supported by grants from Shanghai Municipal Science and Technology Major Project (grant ZD2021CY001 to H.Y.); the Chinese Ministry of Education; Lingang Laboratory (grant LG202101-01-07 to H.Y.); the National Natural Science Foundation of China (grants 82130105, 82121005 and 92253305 to H.L. and grant 81902063 to W.W.); the Strategic Priority Research Program of Chinese Academy of Sciences (grant XDB0490000 to L.Z.); the Hubei Natural Science Foundation for Distinguished Young Scholars (grant 2022CFA099 to L.Z.); the Chongqing Science and Technology Bureau (grant CSTB2024NSCQ-MSX0391 to W.W.); the Chongqing Municipal Education Commission (grant KJQN202400433 to W.W.); the Shanghai Rising Star Program (grant 23QA1406400 to Y.G.); the Joint Funds of the National Natural Science Foundation of China (grant U22A20379 to W.D.); the Postdoctoral Fellowship Program and China Postdoctoral Science Foundation (grants BX20240374 and 2024M753225 to H.W.); and Shanghai Frontiers Science Center for Biomacromolecules and Precision Medicine of Shanghai Tech University.