Journal article
Substrates of hydroxyketoglutarate aldolase
Bioorganic chemistry, Vol.12(3), pp.229-234
1984
DOI: 10.1016/0045-2068(84)90006-3
Abstract
The substrate specificity of the condensation reaction catalyzed by rat liver 4-hydroxy-2-ketoglutarate aldolase has been investigated. It was found that an enzyme-mediated condensation between-glyoxylate and several “activated” carbonyl compounds could be performed. Two classes of these “activated” carbonyls were tested—the first of which are pyruvate analogs differing by substitution at C-3, whereas the second include some C-1 analogs of pyruvate as well as other simple carbonyl compounds. The possible synthetic uses of such a system are discussed as well as possible insights into the structure of the active site of this enzyme.
Details
- Title: Subtitle
- Substrates of hydroxyketoglutarate aldolase
- Creators
- John M. Scholtz - University of Nebraska–LincolnSheldon M. Schuster - University of Nebraska–Lincoln
- Resource Type
- Journal article
- Publication Details
- Bioorganic chemistry, Vol.12(3), pp.229-234
- Publisher
- Elsevier Inc
- DOI
- 10.1016/0045-2068(84)90006-3
- ISSN
- 0045-2068
- eISSN
- 1090-2120
- Language
- English
- Date published
- 1984
- Academic Unit
- Research Administration; Pharmaceutical Sciences and Experimental Therapeutics; Biochemistry and Molecular Biology; Chemistry
- Record Identifier
- 9984288730702771
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