Journal article
Subversion of the Endocytic and Secretory Pathways by Bacterial Effector Proteins
Frontiers in cell and developmental biology, Vol.6, pp.1-1
01/24/2018
DOI: 10.3389/fcell.2018.00001
PMCID: PMC5787570
PMID: 29417046
Abstract
Intracellular bacteria have developed numerous strategies to hijack host vesicular trafficking pathways to form their unique replicative niches. To promote intracellular replication, the bacteria must interact with host organelles and modulate host signaling pathways to acquire nutrients and membrane for the growing parasitophorous vacuole all while suppressing activation of the immune response. To facilitate host cell subversion, bacterial pathogens use specialized secretion systems to deliver bacterial virulence factors, termed effectors, into the host cell that mimic, agonize, and/or antagonize the function of host proteins. In this review we will discuss how bacterial effector proteins from
Coxiella burnetii, Brucella abortus, Salmonella enterica
serovar Typhimurium,
Legionella pneumophila, Chlamydia trachomatis
, and
Orientia tsutsugamushi
manipulate the endocytic and secretory pathways. Understanding how bacterial effector proteins manipulate host processes not only gives us keen insight into bacterial pathogenesis, but also enhances our understanding of how eukaryotic membrane trafficking is regulated.
Details
- Title: Subtitle
- Subversion of the Endocytic and Secretory Pathways by Bacterial Effector Proteins
- Creators
- Mary M Weber - ,Robert Faris - ,
- Resource Type
- Journal article
- Publication Details
- Frontiers in cell and developmental biology, Vol.6, pp.1-1
- DOI
- 10.3389/fcell.2018.00001
- PMID
- 29417046
- PMCID
- PMC5787570
- NLM abbreviation
- Front Cell Dev Biol
- ISSN
- 2296-634X
- eISSN
- 2296-634X
- Publisher
- Frontiers Media S.A
- Language
- English
- Date published
- 01/24/2018
- Academic Unit
- Molecular Physiology and Biophysics; Microbiology and Immunology
- Record Identifier
- 9984083263702771
Metrics
30 Record Views