Journal article
Successful autologous peripheral blood stem cell collection using large volume leukapheresis in patients with very low or undetectable peripheral blood CD34+ progenitor cells
Transfusion and apheresis science, Vol.60(4), pp.103170-103170
08/2021
DOI: 10.1016/j.transci.2021.103170
Abstract
Autologous stem cell transplantation provides some patients with hematolymphoid and solid organ malignancies an opportunity for cure. Management of peripheral hematopoietic stem cell (HSC) collections differs among institutions, especially if a very low pre-procedure peripheral blood CD34+ cell count (PBCD34) is demonstrated. This study retrospectively analyzed results of large-volume peripheral HSC collections in 91 patients over approximately two years. Fifteen patients with PBCD34 < 10 × 10e6/l (eleven with undetectable PBCD34) were compared to 76 patients with higher counts on the first collection day (adequate mobilizers). The poor mobilizer group had significantly lower pre-collection WBC and platelet counts as well as collection yields. However, most patients with PBCD34 < 10 × 10e6/l (80 %) collected the minimum target for HSC transplant (2.0 × 10e6 CD34+ cells/kg) in <5 consecutive days of collection, and those who did collect the minimum successfully underwent autologous transplantation, with hematopoietic engraftment and long-term survival comparable to the adequate mobilizers. Successful HSC collection may often be achieved regardless of d 1 PBCD34 counts.
Details
- Title: Subtitle
- Successful autologous peripheral blood stem cell collection using large volume leukapheresis in patients with very low or undetectable peripheral blood CD34+ progenitor cells
- Creators
- Eric Destrampe - University of IowaAnnette J Schlueter - University of Iowa
- Resource Type
- Journal article
- Publication Details
- Transfusion and apheresis science, Vol.60(4), pp.103170-103170
- Publisher
- Elsevier Ltd
- DOI
- 10.1016/j.transci.2021.103170
- ISSN
- 1473-0502
- eISSN
- 1878-1683
- Language
- English
- Date published
- 08/2021
- Academic Unit
- Pathology
- Record Identifier
- 9984186495002771
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