Journal article
Successful use of cytarabine and bendamustine in a patient with mantle cell lymphoma and acute renal failure using intermittent hemodialysis: A case report
Journal of oncology pharmacy practice, Vol.25(3), pp.731-734
04/01/2019
DOI: 10.1177/1078155217754244
PMID: 29385883
Abstract
Mantle cell lymphoma is a mature B-cell non-Hodgkin lymphoma characterized by the hallmark (11;14) chromosomal translocation, which often presents with lymphadenopathy and extra-nodal involvement. Young, fit patients are generally treated with chemotherapy approaches that incorporate high-dose cytarabine (e.g. the Nordic regimen) followed by autologous hematopoietic cell transplantation. Because of the significant activity of cytarabine in mantle cell lymphoma, increasingly, high- and intermediate-dose cytarabine are being used in the treatment of elderly mantle cell lymphoma patients. In practice, many patients present with significant organ dysfunction and there is limited data on the use of high- to intermediate-dose cytarabine and bendamustine in this setting. Here, we report a case of a critically ill, elderly patient with mantle cell lymphoma and concomitant acute kidney injury and oliguria who was successfully treated with a cycle of cytarabine (Ara-C) and bendamustine accompanied by intermittent hemodialysis.
Details
- Title: Subtitle
- Successful use of cytarabine and bendamustine in a patient with mantle cell lymphoma and acute renal failure using intermittent hemodialysis: A case report
- Creators
- Matthew Ettleson - University of Michigan–Ann ArborKale S. Bongers - University of Michigan–Ann ArborKaitlyn Vitale - University of Michigan–Ann ArborAnthony J. Perissinotti - University of Michigan–Ann ArborTycel Phillips - University of Michigan–Ann ArborBernard L. Marini - University of Michigan–Ann Arbor
- Resource Type
- Journal article
- Publication Details
- Journal of oncology pharmacy practice, Vol.25(3), pp.731-734
- Publisher
- Sage
- DOI
- 10.1177/1078155217754244
- PMID
- 29385883
- ISSN
- 1078-1552
- eISSN
- 1477-092X
- Number of pages
- 4
- Language
- English
- Date published
- 04/01/2019
- Academic Unit
- Internal Medicine
- Record Identifier
- 9984696657602771
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