Journal article
Sucrose diacrylate: A unique chemically and biologically degradable crosslinker for polymeric hydrogels
Journal of polymer science. Part A, Polymer chemistry, Vol.35(11), pp.2221-2229
08/1997
DOI: 10.1002/(SICI)1099-0518(199708)35:11<2221::AID-POLA12>3.0.CO;2-G
Abstract
A series of degradable hydrogels based on different vinyl monomers such as acrylamide, sucrose‐1′‐acrylate, and acrylic acid were synthesized using sucrose‐6,1′‐diacrylate (SDA) as a crosslinking agent. SDA was prepared by enzymatic transesterification of vinyl acrylate with sucrose in pyridine. Base catalyzed hydrolysis of SDA in aqueous solution was studied as a function of pH. As expected, hydrolysis of SDA was faster at higher pHs such that poly(acrylamide), poly(sucrose 1′‐acrylate), and poly(acrylic acid) hydrogels underwent substantial degradation at and above pH 7, 9, and 13, respectively. The degradation was characterized by changes in the swelling ratios of the hydrogels indicating breakage of the crosslinking agent. Degradation of the hydrogels at their chemically stable pHs was studied in presence of enzymes. Enzymes, including pepsin and a fungal Lipase, were able to degrade the poly(acrylamide) hydrogel at pH 4 and 5, respectively. Poly(acrylic acid) hydrogel was degraded in presence of a fungal protease at pH 7.8. © 1997 John Wiley & Sons, Inc. J Polym Sci A: Polym Chem 35: 2221–2229, 1997
Details
- Title: Subtitle
- Sucrose diacrylate: A unique chemically and biologically degradable crosslinker for polymeric hydrogels
- Creators
- Nitin S PatilYanzi LiDavid G RethwischJonathan S Dordick
- Resource Type
- Journal article
- Publication Details
- Journal of polymer science. Part A, Polymer chemistry, Vol.35(11), pp.2221-2229
- Publisher
- John Wiley & Sons, Inc; New York
- DOI
- 10.1002/(SICI)1099-0518(199708)35:11<2221::AID-POLA12>3.0.CO;2-G
- ISSN
- 0887-624X
- eISSN
- 1099-0518
- Number of pages
- 9
- Grant note
- Biotechnology Research and Development Corp. USDA (Byproducts from Biotechnology Consortium)
- Language
- English
- Date published
- 08/1997
- Academic Unit
- Chemical and Biochemical Engineering
- Record Identifier
- 9984004087102771
Metrics
25 Record Views