Journal article
Sucrose ingestion elicits reduced Fos expression in the nucleus accumbens of anhedonic rats
Brain research, Vol.1019(1-2), pp.259-264
09/03/2004
DOI: 10.1016/j.brainres.2004.05.019
PMID: 15306261
Abstract
Chronic mild stress (CMS), an animal model of depression associated with anhedonia, was used to examine nucleus accumbens (NAc) activation associated with a rewarding stimulus. Following 4 weeks of CMS in rats, NAc Fos-immunoreactivity was measured after ingestion of a fixed volume of sucrose. Fewer Fos-positive neurons were observed in the NAc in CMS versus control rats. These findings have implications for the mechanisms underlying reduced responding to pleasurable stimuli associated with depression.
Details
- Title: Subtitle
- Sucrose ingestion elicits reduced Fos expression in the nucleus accumbens of anhedonic rats
- Creators
- Angela J Grippo - Departments of Psychology and Pharmacology and the Cardiovascular Center, University of Iowa, 11 Seashore Hall E, Iowa City, IA 52242-1407, USAElisa S NaRalph F JohnsonTerry G BeltzAlan Kim Johnson
- Resource Type
- Journal article
- Publication Details
- Brain research, Vol.1019(1-2), pp.259-264
- DOI
- 10.1016/j.brainres.2004.05.019
- PMID
- 15306261
- ISSN
- 0006-8993
- eISSN
- 1872-6240
- Grant note
- HL-14388 / NHLBI NIH HHS MH-65839 / NIMH NIH HHS HL-57472 / NHLBI NIH HHS
- Language
- English
- Date published
- 09/03/2004
- Academic Unit
- Psychological and Brain Sciences; Neuroscience and Pharmacology; Health and Human Physiology
- Record Identifier
- 9984214758302771
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