Journal article
Sudden Hearing Loss Associated with Tacrolimus in a Kidney-Pancreas Allograft Recipient
Pharmacotherapy: The Journal of Human Pharmacology and Drug Therapy, Vol.19(7), pp.891-893
07/1999
DOI: 10.1592/phco.19.10.891.31562
Abstract
A 38-year-old woman with type 1 diabetes underwent kidney-pancreas transplantation. Her postoperative course was complicated due to recurrent acute graft rejections and pancreatitis. After initial immunosuppression with microemulsion cyclosporine, mycophenolate mofetil, and prednisone with muromonab-CD3 induction, cyclosporine was switched to tacrolimus on day 44. The initial dosage was 5 mg twice/day, but it was gradually increased to 10 mg twice/day, aiming at 15–20 ng/ml. On day 17 of tacrolimus therapy the woman developed sudden hearing loss with tinnitus. The serum tacrolimus level was 28.3 ng/ml (therapeutic range 10–20 ng/ml) on day 20 of tacrolimus therapy, and peaked at 34.9 ng/ml on day 28. Two audiograms performed on days 28 and 29 confirmed bilateral hearing loss of 80% for speech perception, characterized as mild to moderate sensorineural hearing loss with speech reception threshold of 35 dB (normal < 20 dB) in both ears. The tacrolimus dosage was gradually reduced to 6 mg twice/day by day 36, with drug level 9.7 ng/ml, after which her hearing gradually recovered.
Details
- Title: Subtitle
- Sudden Hearing Loss Associated with Tacrolimus in a Kidney-Pancreas Allograft Recipient
- Creators
- David I. Min - College of Pharmacy, the University of Iowa, Iowa City, IowaYi-Min Ku - University of IowaStephen Rayhill - University of IowaClaudia Corwin - University of IowaYou-Min Wu - University of IowaLawrence G. Hunsicker - University of Iowa
- Resource Type
- Journal article
- Publication Details
- Pharmacotherapy: The Journal of Human Pharmacology and Drug Therapy, Vol.19(7), pp.891-893
- DOI
- 10.1592/phco.19.10.891.31562
- ISSN
- 0277-0008
- eISSN
- 1875-9114
- Publisher
- Blackwell Publishing Ltd; Oxford, UK
- Number of pages
- 3
- Language
- English
- Date published
- 07/1999
- Academic Unit
- Pulmonary, Critical Care, and Occupational Medicine; Occupational and Environmental Health; International Programs; Nephrology; Internal Medicine
- Record Identifier
- 9984359898602771
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