Sudden unexpected death in epilepsy: Identifying risk and preventing mortality

Samden Lhatoo; Jeffrey Noebels; Vicky Whittemore; National Institute of Neurological Disorders and Stroke (NINDS) Center for Sudden Unexpected Death in Epilepsy (SUDEP) Research

doi:10.1111/epi.13134

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Sudden unexpected death in epilepsy: Identifying risk and preventing mortality

Journal article

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Peer reviewed

Sudden unexpected death in epilepsy: Identifying risk and preventing mortality

Samden Lhatoo, Jeffrey Noebels, Vicky Whittemore and National Institute of Neurological Disorders and Stroke (NINDS) Center for Sudden Unexpected Death in Epilepsy (SUDEP) Research

Epilepsia (Copenhagen), Vol.56(11), pp.1700-1706

11/2015

DOI: 10.1111/epi.13134

PMCID: PMC4852129

PMID: 26494436

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Abstract

Premature death among individuals with epilepsy is higher than in the general population, and sudden unexpected death is the most common cause of this mortality. A new multisite collaborative research consortium, the Center for sudden unexpected death in epilepsy (SUDEP) Research (CSR), has received major funding from the National Institutes of Health (NIH) to examine the possible biologic mechanisms underlying this potentially preventable comorbidity and develop predictive biomarkers for interventions that could lower SUDEP incidence. This inaugural report describes the structure of the CSR, its priorities for human and experimental research, and the strategic collaborations and advanced tools under development to reduce this catastrophic outcome of epilepsy. The CSR Partners Program will work closely with committed volunteer agencies, industry, and academic institutions to accelerate and communicate these advances to the professional and lay community.

Death, Sudden - epidemiology

Death, Sudden - etiology

Humans

Risk Factors

Biomedical Research - trends

Epilepsy - mortality

Mortality - trends

Death, Sudden - prevention & control

Epilepsy - therapy

Epilepsy - diagnosis

Details

Title: Subtitle: Sudden unexpected death in epilepsy: Identifying risk and preventing mortality
Creators: Samden Lhatoo - Neurology, Case Western Reserve University, Cleveland, Ohio, U.S.A
Jeffrey Noebels - Neurology, Baylor College of Medicine, Houston, Texas, U.S.A
Vicky Whittemore - Program Director-Epilepsy Channels, Synapses and Circuits, NINDS/NIH, Rockville, Maryland, U.S.A
National Institute of Neurological Disorders and Stroke (NINDS) Center for Sudden Unexpected Death in Epilepsy (SUDEP) Research
Contributors: George B Richerson (Contributor) - University of Iowa, Molecular Physiology and Biophysics
Katherine D Mathews (Contributor) - University of Iowa, Stead Family Department of Pediatrics
Resource Type: Journal article
Publication Details: Epilepsia (Copenhagen), Vol.56(11), pp.1700-1706
DOI: 10.1111/epi.13134
PMID: 26494436
PMCID: PMC4852129
NLM abbreviation: Epilepsia
ISSN: 0013-9580
eISSN: 1528-1167
Publisher: United States
Grant note: U01-NS090405 / NINDS NIH HHS P20 NS076916 / NINDS NIH HHS U01-NS090362 / NINDS NIH HHS U01 NS090405 / NINDS NIH HHS U01 NS090408 / NINDS NIH HHS U01 NS090364 / NINDS NIH HHS U01-NS090364 / NINDS NIH HHS U01 NS090407 / NINDS NIH HHS U01 NS090340 / NINDS NIH HHS U01-NS090408 / NINDS NIH HHS U01 NS090415 / NINDS NIH HHS U01-NS090414 / NINDS NIH HHS U01-NS090407 / NINDS NIH HHS U01-NS090340 / NINDS NIH HHS U01 NS090406 / NINDS NIH HHS U01-NS090415 / NINDS NIH HHS U01-NS090406 / NINDS NIH HHS U01 NS090414 / NINDS NIH HHS U01 NS090362 / NINDS NIH HHS
Language: English
Date published: 11/2015
Academic Unit: Neurology; Molecular Physiology and Biophysics; Stead Family Department of Pediatrics; Iowa Neuroscience Institute; Neurology (Pediatrics); Neurosurgery
Record Identifier: 9984014865202771

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