Journal article
Sugar-Sweetened Beverage Consumption May Modify Associations Between Genetic Variants in the CHREBP (Carbohydrate Responsive Element Binding Protein) Locus and HDL-C (High-Density Lipoprotein Cholesterol) and Triglyceride Concentrations
Circulation. Genomic and precision medicine, Vol.14(4), pp.506-516
08/2021
DOI: 10.1161/CIRCGEN.120.003288
PMCID: PMC8373451
PMID: 34270325
Abstract
Background: ChREBP (carbohydrate responsive element binding protein) is a transcription factor that responds to sugar consumption. Sugar-sweetened beverage (SSB) consumption and genetic variants in the CHREBP locus have separately been linked to HDL-C (high-density lipoprotein cholesterol) and triglyceride concentrations. We hypothesized that SSB consumption would modify the association between genetic variants in the CHREBP locus and dyslipidemia. Methods: Data from 11 cohorts from the Cohorts for Heart and Aging Research in Genomic Epidemiology consortium (N=63 599) and the UK Biobank (N=59 220) were used to quantify associations of SSB consumption, genetic variants, and their interaction on HDL-C and triglyceride concentrations using linear regression models. A total of 1606 single nucleotide polymorphisms within or near CHREBP were considered. SSB consumption was estimated from validated questionnaires, and participants were grouped by their estimated intake. Results: In a meta-analysis, rs71556729 was significantly associated with higher HDL-C concentrations only among the highest SSB consumers (β, 2.12 [95% CI, 1.16–3.07] mg/dL per allele; P <0.0001), but not significantly among the lowest SSB consumers ( P =0.81; P Diff <0.0001). Similar results were observed for 2 additional variants (rs35709627 and rs71556736). For triglyceride, rs55673514 was positively associated with triglyceride concentrations only among the highest SSB consumers (β, 0.06 [95% CI, 0.02–0.09] ln-mg/dL per allele, P =0.001) but not the lowest SSB consumers ( P =0.84; P Diff =0.0005). Conclusions: Our results identified genetic variants in the CHREBP locus that may protect against SSB-associated reductions in HDL-C and other variants that may exacerbate SSB-associated increases in triglyceride concentrations. Registration: URL: https://www.clinicaltrials.gov ; Unique identifier: NCT00005133, NCT00005121, NCT00005487, and NCT00000479.
Details
- Title: Subtitle
- Sugar-Sweetened Beverage Consumption May Modify Associations Between Genetic Variants in the CHREBP (Carbohydrate Responsive Element Binding Protein) Locus and HDL-C (High-Density Lipoprotein Cholesterol) and Triglyceride Concentrations
- Creators
- Danielle E Haslam - Nutritional Epidemiology Program (D.E.H., M. Guirette, K.A.L., N.M.M.), Tufts University, Boston, MA., Channing Division of Network Medicine (D.E.H., J.E.M.), Brigham and Women's Hospital and Harvard Medical School, Boston, MA., Department of Nutrition (D.E.H.), Harvard T.H. Chan School of Public Health, Boston, MAGina M Peloso - Department of Biostatistics, Boston University School of Public Health, MA (G.M.P., A.N.P., J.D.)Melanie Guirette - Nutritional Epidemiology Program (D.E.H., M. Guirette, K.A.L., N.M.M.), Tufts University, Boston, MAFumiaki Imamura - Medical Research Council Epidemiology Unit, University of Cambridge, United Kingdom (F.I., J.L., N.G.F., N.J.W.)Traci M Bartz - Cardiovascular Health Research Unit, Departments of Biostatistics (T.M.B.), University of Washington, Seattle., Department of Medicine (T.M.B., R.N.L., B.M.P.), University of Washington, SeattleAchilleas N Pitsillides - Department of Biostatistics, Boston University School of Public Health, MA (G.M.P., A.N.P., J.D.)Carol A Wang - School of Medicine and Public Health, Faculty of Medicine and Health, The University of Newcastle, NSW, Australia (C.A.W., C.E.P.)Ruifang Li-Gao - Department of Clinical Epidemiology (R.L.G., D.O.M.-K., F.R.R., R.dM.), Leiden University Medical Center, the NetherlandsJason M Westra - Dordt University, Sioux Center, IA (J.M.W., N.T.)Niina Pitkänen - Auria Biobank (N.P.), University of Turku, Finland., Research Centre of Applied and Preventive Cardiovascular Medicine (N.P., O.T.R.), University of Turku, FinlandKristin L Young - Department of Epidemiology, Gillings School of Global Public Health (K.L.Y., M. Graff, K.N.), University of North Carolina, Chapel HillMariaelisa Graff - Department of Epidemiology, Gillings School of Global Public Health (K.L.Y., M. Graff, K.N.), University of North Carolina, Chapel HillAlexis C Wood - USDA/ARS Children's Nutrition Research Center, Department of Pediatrics, Baylor College of Medicine, Houston, TX (A.C.W.)Kim V.E Braun - Department of Epidemiology (K.V.E.B., J.C.K.-d.J., M. Ghanbari, M.A.I.), Erasmus MC University Medical Center Rotterdam, the NetherlandsJian’an Luan - Medical Research Council Epidemiology Unit, University of Cambridge, United Kingdom (F.I., J.L., N.G.F., N.J.W.)Mika Kähönen - Department of Clinical Physiology (M.K.), Tampere University Hospital, Finland., Department of Clinical Physiology (M.K.), Finnish Cardiovascular Research Center-Tampere, Faculty of Medicine and Life Sciences, University of Tampere, FinlandJessica C Kiefte-de Jong - Department of Public Health and Primary Care (J.C.L.d.J., D.O.M.-K.), Leiden University Medical Center, the Netherlands., Department of Epidemiology (K.V.E.B., J.C.K.-d.J., M. Ghanbari, M.A.I.), Erasmus MC University Medical Center Rotterdam, the NetherlandsMohsen Ghanbari - Department of Epidemiology (K.V.E.B., J.C.K.-d.J., M. Ghanbari, M.A.I.), Erasmus MC University Medical Center Rotterdam, the NetherlandsNathan Tintle - Dordt University, Sioux Center, IA (J.M.W., N.T.)Rozenn N Lemaitre - Department of Medicine (T.M.B., R.N.L., B.M.P.), University of Washington, SeattleDennis O Mook-Kanamori - Department of Clinical Epidemiology (R.L.G., D.O.M.-K., F.R.R., R.dM.), Leiden University Medical Center, the Netherlands., Department of Public Health and Primary Care (J.C.L.d.J., D.O.M.-K.), Leiden University Medical Center, the NetherlandsKari North - Department of Epidemiology, Gillings School of Global Public Health (K.L.Y., M. Graff, K.N.), University of North Carolina, Chapel Hill., Carolina Center for Genome Science (K.N.), University of North Carolina, Chapel HillMika Helminen - Research Development and Innovation Centre (M.H.), Tampere University Hospital, Finland., Faculty of Social Sciences, Health Sciences, Tampere University, Finland (M.H.)Yasmin Mossavar-Rahmani - Department of Epidemiology and Population Health, Albert Einstein College of Medicine, Bronx, NY (Y.M.-R.)Linda Snetselaar - Department of Epidemiology, University of Iowa, Iowa City (L.S.)Lisa W Martin - George Washington University School of Medicine and Health Sciences, Washington, D.C. (L.W.M.)Jorma S Viikari - Department of Medicine (J.S.V.), University of Turku, Finland., Division of Medicine (J.S.V.), Turku University Hospital, FinlandWendy H Oddy - Menzies Institute for Medical Research, University of Tasmania, HOB, Australia (W.H.O.)Craig E Pennell - Nutrition and Genomics Laboratory (C.E.S.), Tufts University, Boston, MA., School of Medicine and Public Health, Faculty of Medicine and Health, The University of Newcastle, NSW, Australia (C.A.W., C.E.P.)Frits R Rosendall - Department of Clinical Epidemiology (R.L.G., D.O.M.-K., F.R.R., R.dM.), Leiden University Medical Center, the NetherlandsM. Arfan Ikram - Department of Epidemiology (K.V.E.B., J.C.K.-d.J., M. Ghanbari, M.A.I.), Erasmus MC University Medical Center Rotterdam, the NetherlandsAndre G Uitterlinden - Department of Internal Medicine (A.G.U.), Erasmus MC University Medical Center Rotterdam, the NetherlandsBruce M Psaty - Department of Medicine (T.M.B., R.N.L., B.M.P.), University of Washington, Seattle., Departments of Epidemiology and Health Services (B.M.P.), University of Washington, Seattle., Kaiser Permanente Washington Health Research Institute, Seattle, WA (B.M.P.)Dariush Mozaffarian - Jean Mayer U.S. Department of Agriculture Human Nutrition Research Center on Aging, and Friedman School of Nutrition Science and Policy (D.M.), Tufts University, Boston, MAJerome I Rotter - The Institute for Translational Genomics and Population Sciences, Department of Pediatrics, The Lundquist Institute for Biomedical Innovation at Harbor-UCLA Medical Center, Torrance, CA (J.I.R., K.D.T.)Kent D Taylor - The Institute for Translational Genomics and Population Sciences, Department of Pediatrics, The Lundquist Institute for Biomedical Innovation at Harbor-UCLA Medical Center, Torrance, CA (J.I.R., K.D.T.)Terho Lehtimäki - Department of Clinical Chemistry (T.L.), Finnish Cardiovascular Research Center-Tampere, Faculty of Medicine and Life Sciences, University of Tampere, Finland., Department of Clinical Chemistry, Fimlab Laboratories, Tampere, Finland (T.L.)Olli T Raitakari - Research Centre of Applied and Preventive Cardiovascular Medicine (N.P., O.T.R.), University of Turku, Finland., Centre for Population Health Research (O.T.R.), University of Turku, Finland., Department of Clinical Physiology and Nuclear Medicine (O.T.R.), Turku University Hospital, FinlandKara A Livingston - Nutritional Epidemiology Program (D.E.H., M. Guirette, K.A.L., N.M.M.), Tufts University, Boston, MATrudy VoortmanNita G Forouhi - Medical Research Council Epidemiology Unit, University of Cambridge, United Kingdom (F.I., J.L., N.G.F., N.J.W.)Nick J Wareham - Medical Research Council Epidemiology Unit, University of Cambridge, United Kingdom (F.I., J.L., N.G.F., N.J.W.)Renée de Mutsert - Department of Clinical Epidemiology (R.L.G., D.O.M.-K., F.R.R., R.dM.), Leiden University Medical Center, the NetherlandsSteven S Rich - Center for Public Health Genomics and Department of Public Health Sciences, University of Virginia School of Medicine, Charlottesville (S.S.R.)JoAnn E Manson - Channing Division of Network Medicine (D.E.H., J.E.M.), Brigham and Women's Hospital and Harvard Medical School, Boston, MA., Division of Preventive Medicine (J.E.M., S.M., P.M.R., D.I.C.), Brigham and Women's Hospital and Harvard Medical School, Boston, MA., Department of Epidemiology (J.E.M.), Harvard T.H. Chan School of Public Health, Boston, MASamia Mora - Division of Preventive Medicine (J.E.M., S.M., P.M.R., D.I.C.), Brigham and Women's Hospital and Harvard Medical School, Boston, MA., Cardiovascular Division of Medicine and Center for Lipid Metabolomics (S.M., P.M.R.), Brigham and Women's Hospital and Harvard Medical School, Boston, MAPaul M Ridker - Division of Preventive Medicine (J.E.M., S.M., P.M.R., D.I.C.), Brigham and Women's Hospital and Harvard Medical School, Boston, MA., Cardiovascular Division of Medicine and Center for Lipid Metabolomics (S.M., P.M.R.), Brigham and Women's Hospital and Harvard Medical School, Boston, MAJordi Merino - Program in Medical and Population Genetics (J.M., J.B.M., H.S.D.), Broad Institute of MIT and Harvard, Cambridge, MA., Program in Metabolism (J.M., J.B.M.), Broad Institute of MIT and Harvard, Cambridge, MA., Department of Medicine, Harvard Medical School, Boston, MA (J.M., J.B.M.)., Institut d'Investigació Sanitària Pere Virgili, Universitat Rovira i Virgili, Reus, Spain (J.M.)., Diabetes Unit and Center for Genomic Medicine (J.M., H.S.D.), Massachusetts General Hospital and Harvard Medical School, BostonJames B Meigs - Program in Medical and Population Genetics (J.M., J.B.M., H.S.D.), Broad Institute of MIT and Harvard, Cambridge, MA., Program in Metabolism (J.M., J.B.M.), Broad Institute of MIT and Harvard, Cambridge, MA., Department of Medicine, Harvard Medical School, Boston, MA (J.M., J.B.M.)., Division of General Internal Medicine (J.B.M.), Massachusetts General Hospital and Harvard Medical School, BostonHassan S Dashti - Program in Medical and Population Genetics (J.M., J.B.M., H.S.D.), Broad Institute of MIT and Harvard, Cambridge, MA., Diabetes Unit and Center for Genomic Medicine (J.M., H.S.D.), Massachusetts General Hospital and Harvard Medical School, Boston., Department of Anesthesia, Critical Care and Pain Medicine (H.S.D.), Massachusetts General Hospital and Harvard Medical School, BostonDaniel I Chasman - Division of Preventive Medicine (J.E.M., S.M., P.M.R., D.I.C.), Brigham and Women's Hospital and Harvard Medical School, Boston, MAAlice H Lichtenstein - Cardiovascular Nutrition Laboratory (A.H.L.), Tufts University, Boston, MACaren E SmithJosée Dupuis - Department of Biostatistics, Boston University School of Public Health, MA (G.M.P., A.N.P., J.D.)Mark A Herman - Division Of Endocrinology, Metabolism, and Nutrition, Department of Medicine and Duke Molecular Physiology Institute, Duke University School of Medicine, Durham, NC (M.A.H.)Nicola M McKeown - Nutritional Epidemiology Program (D.E.H., M. Guirette, K.A.L., N.M.M.), Tufts University, Boston, MA
- Resource Type
- Journal article
- Publication Details
- Circulation. Genomic and precision medicine, Vol.14(4), pp.506-516
- DOI
- 10.1161/CIRCGEN.120.003288
- PMID
- 34270325
- PMCID
- PMC8373451
- NLM abbreviation
- Circ Genom Precis Med
- ISSN
- 2574-8300
- eISSN
- 2574-8300
- Language
- English
- Date published
- 08/2021
- Academic Unit
- Epidemiology; Fraternal Order of Eagles Diabetes Research Center; Internal Medicine
- Record Identifier
- 9984215041202771
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