Journal article
Suggestive linkage to chromosomal regions 13q31 and 22q12 in families with psychotic bipolar disorder
The American journal of psychiatry, Vol.160(4), pp.680-686
2003
DOI: 10.1176/appi.ajp.160.4.680
PMID: 12668356
Abstract
OBJECTIVE: Linkage studies of bipolar disorder and schizophrenia have found overlapping evidence for susceptibility genes in four chromosomal regions—10p12-14, 13q32, 18p11.2, and 22q12-13. The authors previously demonstrated familial clustering of psychotic symptoms—defined as hallucinations and/or delusions—in some bipolar disorder pedigrees. In this study they used stratified linkage analysis to test the hypothesis that those bipolar disorder pedigrees most enriched for psychotic symptoms would show greater evidence of linkage to the regions of previous bipolar disorder/schizophrenia linkage overlap. METHOD: Nonparametric linkage analyses using GENEHUNTER and ASPEX were performed on 65 bipolar disorder families. Family subsets were defined by the number of family members with psychotic mood disorder. RESULTS: The 10 families in which three or more members had psychotic mood disorder showed suggestive evidence of linkage to 13q31 (nonparametric linkage score=3.56; LOD score=2.52) and 22q12 (nonparametric linkage score=3.32; LOD score=3.06). These results differed significantly from those for the entire study group of 65 families, which showed little or no linkage evidence in the two regions. The 10 families with three or more psychotic members did not show evidence of linkage to 10p12-14 or 18p11.2. The 95% confidence interval on 22q12 spanned 4.3 centimorgans (2.6 megabases) and was congruent with previous findings. CONCLUSIONS: Bipolar disorder families in which psychotic symptoms cluster may carry susceptibility genes on chromosomal regions 13q31 and 22q12. Replication should be attempted in similar families and perhaps in schizophrenia families in which mood symptoms cluster because these overlapping phenotypes may correlate most closely with the putative susceptibility genes. The localization of the 22q12 finding particularly encourages further study of this region.
Details
- Title: Subtitle
- Suggestive linkage to chromosomal regions 13q31 and 22q12 in families with psychotic bipolar disorder
- Creators
- James B POTASH - Department of Psychiatry and Behavioral Sciences, Johns Hopkins School of Medicine, Baltimore, United StatesVirginia L WILLOUR - Department of Psychiatry and Behavioral Sciences, Johns Hopkins School of Medicine, Baltimore, United StatesPeter P ZANDI - Department of Psychiatry and Behavioral Sciences, Johns Hopkins School of Medicine, Baltimore, United StatesJ. Raymond DEPAULO - Department of Psychiatry and Behavioral Sciences, Johns Hopkins School of Medicine, Baltimore, United StatesMelvin G MCLNNIS - Department of Psychiatry and Behavioral Sciences, Johns Hopkins School of Medicine, Baltimore, United StatesTsuo-Hung LAN - Department of Psychiatry and Behavioral Sciences, Johns Hopkins School of Medicine, Baltimore, United StatesYuqing Huo - Department of Psychiatry and Behavioral Sciences, Johns Hopkins School of Medicine, Baltimore, United StatesDimitrios AVRAMOPOULOS - Department of Psychiatry and Behavioral Sciences, Johns Hopkins School of Medicine, Baltimore, United StatesYin Y SHUGART - Department of Psychiatry and Behavioral Sciences, Johns Hopkins School of Medicine, Baltimore, United StatesDean F MACKINNON - Department of Psychiatry and Behavioral Sciences, Johns Hopkins School of Medicine, Baltimore, United StatesSylvia G SIMPSON - Department of Psychiatry and Behavioral Sciences, Johns Hopkins School of Medicine, Baltimore, United StatesFrancis J MCMAHON - Department of Psychiatry and Behavioral Sciences, Johns Hopkins School of Medicine, Baltimore, United States
- Resource Type
- Journal article
- Publication Details
- The American journal of psychiatry, Vol.160(4), pp.680-686
- Publisher
- American Psychiatric Association; Washington, DC
- DOI
- 10.1176/appi.ajp.160.4.680
- PMID
- 12668356
- ISSN
- 0002-953X
- eISSN
- 1535-7228
- Language
- English
- Date published
- 2003
- Academic Unit
- Psychiatry; Iowa Neuroscience Institute
- Record Identifier
- 9984070773102771
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