Journal article
Suicidal Behavior in Prodromal Huntington Disease
Neuro-degenerative diseases, Vol.8(6), pp.483-490
08/2011
DOI: 10.1159/000327754
PMCID: PMC3186721
PMID: 21659725
Abstract
Background: Several studies have suggested a greater risk of suicide in Huntington disease (HD); however, unique risk factors for suicide in HD are not established. Objective: We sought to determine risk factors for suicidal behavior, defined as suicide or attempted suicide, in prodromal HD. Methods: From the prospective PREDICT-HD cohort, we identified 735 cases with HD gene expansion but no manifest symptoms of HD and 194 non-gene-expanded controls. In survival analysis, a number of potential risk factors for suicidal behavior were assessed, including symptoms of depression, hopelessness, substance abuse, marital status, gender, and psychiatric history. Results: During a mean of 3.7 years of prospective follow-up, 12 cases (1.6%) attempted suicide and 1 completed suicide (0.1%). No suicides were observed among controls. In univariate Cox proportional hazards regression models, a history of suicide attempts (HR 8.5, 95% CI 2.8–26.1, p < 0.0002) and a Beck Depression Inventory II score >13 (HR 7.2, 95% CI 2.3–22.0, p < 0.0006) were associated with suicidal behavior. These risk factors had independent effects in multivariate models. A history of incarceration in the past 2 years was also associated (HR 12.5, 95% CI 2.7–56.6, p < 0.002), though uncommon. No further risk factors were identified. Conclusion: A history of suicide attempts and the presence of depression are strongly predictive of suicidal behavior in prodromal HD. As these risk factors are among the most robust risk factors for suicide, established suicide risk factors appear applicable to those with prodromal HD.
Details
- Title: Subtitle
- Suicidal Behavior in Prodromal Huntington Disease
- Creators
- Jess G FiedorowiczJames A MillsAdam RuggleDouglas LangbehnJane S PaulsenPREDICT-HD Investigators of the Huntington Study Group
- Contributors
- Hans J Johnson (Contributor) - University of Iowa, Electrical and Computer Engineering
- Resource Type
- Journal article
- Publication Details
- Neuro-degenerative diseases, Vol.8(6), pp.483-490
- DOI
- 10.1159/000327754
- PMID
- 21659725
- PMCID
- PMC3186721
- NLM abbreviation
- Neurodegener Dis
- ISSN
- 1660-2854
- eISSN
- 1660-2862
- Publisher
- Basel, Switzerland
- Number of pages
- 8
- Language
- English
- Date published
- 08/2011
- Academic Unit
- Roy J. Carver Department of Biomedical Engineering; Electrical and Computer Engineering; Psychiatry; Epidemiology; Psychological and Brain Sciences; Iowa Neuroscience Institute; The Iowa Institute for Biomedical Imaging; The Iowa Initiative for Artificial Intelligence; Iowa Informatics Initiative; Internal Medicine
- Record Identifier
- 9984003920802771
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