Sulfate conjugates are urinary markers of inhalation exposure to 4-chlorobiphenyl (PCB3)

Kiran Dhakal; Andrea Adamcakova-Dodd; Hans-Joachim Lehmler; Peter S Thorne; Larry W Robertson

doi:10.1021/tx4001539

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Sulfate conjugates are urinary markers of inhalation exposure to 4-chlorobiphenyl (PCB3)

Journal article

Open access

Peer reviewed

Sulfate conjugates are urinary markers of inhalation exposure to 4-chlorobiphenyl (PCB3)

Kiran Dhakal, Andrea Adamcakova-Dodd, Hans-Joachim Lehmler, Peter S Thorne and Larry W Robertson

Chemical research in toxicology, Vol.26(6), pp.853-855

06/17/2013

DOI: 10.1021/tx4001539

PMCID: PMC3703249

PMID: 23713983

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Abstract

PCBs are contaminants in the air of older buildings and cities, which raises the concern of inhalation exposure. No reliable biomarker of such exposure is available. We exposed rats to air containing 2 mg/m(3) PCB3 via nose-only inhalation for 2 h, collected urine, and analyzed it by LC/MS. Each rat inhaled an estimated dose of 35 μg PCB3, and excreted 27 ± 2% of it as sulfates within 24 h. Peak excretion occurred within 6 h. PCB sulfates were stable in urine for at least three days at room temperature without chemical preservatives. These data support the use of PCB sulfate conjugates as suitable urinary biomarkers of PCB3 and other airborne PCBs.

Biomarkers - urine

Rats

Biphenyl Compounds - urine

Rats, Sprague-Dawley

Sulfates - urine

Animals

Inhalation Exposure

Biphenyl Compounds - administration & dosage

Sulfates - chemistry

Female

Molecular Structure

Biphenyl Compounds - chemistry

Biomarkers - chemistry

Details

Title: Subtitle: Sulfate conjugates are urinary markers of inhalation exposure to 4-chlorobiphenyl (PCB3)
Creators: Kiran Dhakal - Interdisciplinary Graduate Program in Human Toxicology and Department of Occupational and Environmental Health, University of Iowa, Iowa City, Iowa 52242, USA
Andrea Adamcakova-Dodd
Hans-Joachim Lehmler
Peter S Thorne
Larry W Robertson
Resource Type: Journal article
Publication Details: Chemical research in toxicology, Vol.26(6), pp.853-855
DOI: 10.1021/tx4001539
PMID: 23713983
PMCID: PMC3703249
NLM abbreviation: Chem Res Toxicol
ISSN: 0893-228X
eISSN: 1520-5010
Publisher: United States
Grant note: ES005605 / NIEHS NIH HHS P30 ES005605 / NIEHS NIH HHS P42 ES013661 / NIEHS NIH HHS ES013661 / NIEHS NIH HHS
Language: English
Date published: 06/17/2013
Academic Unit: Civil and Environmental Engineering; Occupational and Environmental Health; Stead Family Department of Pediatrics; Iowa Superfund Research Program
Record Identifier: 9983997311102771

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