Sumoylated Etv1 establishes mouse mammary cancer stem cells that support tumorigenesis by non-stem cancer cells
Abstract
Details
- Title: Subtitle
- Sumoylated Etv1 establishes mouse mammary cancer stem cells that support tumorigenesis by non-stem cancer cells
- Creators
- Zhijie Li - University of IowaKelsey E Koch - University of IowaDakota T Thompson - University of IowaDana M Van der Heide - University of IowaJeremy Chang - Department of Surgery, University of Iowa, Iowa City, IA 52242, USAChristopher M Franke - University of IowaMohammed O Suraju - University of IowaAnna C Beck - University of Iowa, SurgeryAllison W Lorenzen - University of IowaJeffrey R White - University of IowaNicholas I Bartschat - University of Iowa, SurgeryMikhail V Kulak - University of IowaDavid K Meyerholz - University of IowaColin Kenny - University of IowaRonald J Weigel - Department of Surgery, University of Iowa, Iowa City, IA 52242, USA. Electronic address: ronald-weigel@uiowa.edu
- Resource Type
- Journal article
- Publication Details
- Developmental cell, Vol.60(17), pp.2264-2278.e7
- DOI
- 10.1016/j.devcel.2025.04.005
- PMID
- 40315856
- PMCID
- PMC12353075
- NLM abbreviation
- Dev Cell
- ISSN
- 1878-1551
- eISSN
- 1878-1551
- Publisher
- CELL PRESS
- Grant note
- NIH: T32CA148062 Society of University SurgeonsCarver College of MedicineIowa City Veteran's Administration Medical CenterNational Cancer Institute of the National Institutes of Health: P30CA086862
We thank Dr. William Paradee and the staff of the Genome Editing and Viral Vector Cores at The University of Iowa for creation of the FVB/Ube2ifl mouse strain and viral vectors used in this work. We thank Carly Weigel for artwork. This work was supported by the NIH grants R01CA183702 (Principal Investigator: R.J.W.) , T32CA148062 (Principal Investigator: R.J.W.) , DOD/BCRP grant BC200558 (Principal Investigator: R.J.W.) , and by generous gifts from the Kristen Olewine Milke Breast Cancer Research Fund (to R.J.W.) , the Ann Staak Duffy Breast Cancer Research Fund (to R.J.W.) , and a gift from J.D. and Jill Thoreson of Mason City, Iowa (to R.J.W.) . K.E.K., D.T.T., D.M.V.d.H., A.C.B., and A.W.L. were supported by the NIH grant T32CA148062. M.O.S. was supported by a Resident Research Scholar award from the Society of University Surgeons. The data presented herein were obtained at the Flow Cytometry Facility, which is a Carver College of Medicine/Holden Comprehensive Cancer Center core research facility at the University of Iowa. The facility is funded through user fees and the generous financial support of the Carver College of Medicine, Holden Comprehensive Cancer Center, and Iowa City Veteran's Administration Medical Center. Research reported in this publication was supported by the National Cancer Institute of the National Institutes of Health under award number P30CA086862. This research was supported with computational resources from the University of Iowa High Performance Computing Facility and Galaxy.
- Language
- English
- Electronic publication date
- 04/25/2025
- Date published
- 09/2025
- Academic Unit
- Molecular Physiology and Biophysics; Anatomy and Cell Biology; Pathology; Surgery; Biochemistry and Molecular Biology
- Record Identifier
- 9984816012702771