Journal article
Sunscreen or simulated sweat minimizes the impact of acute ultraviolet radiation on cutaneous microvascular function in healthy humans
Experimental physiology, Vol.104(7), pp.1136-1146
07/01/2019
DOI: 10.1113/EP087688
PMCID: PMC6602818
PMID: 31004462
Abstract
Exposure to ultraviolet radiation (UVR) may result in cutaneous vascular dysfunction independent of erythema (skin reddening). Two studies were designed to differentiate changes in erythema from skin vasodilatation throughout the 8 h after acute broad-spectrum UVR exposure with (+SS) or without SPF-50 sunscreen (study1) and to examine NO-mediated cutaneous vasodilatation after acute broad-spectrum UVR exposure with or without +SS or simulated sweat (+SW) on the skin (study 2). In both studies, laser-Doppler flowmetry was used to measure red cell flux, and cutaneous vascular conductance (CVC) was calculated (CVC=flux/mean arterial pressure). In study 1, in 14 healthy adults (24 +/- 4 years old; seven men and seven women), the skin erythema index and CVC were measured over two forearm sites (UVR only and UVR+SS) before, immediately after and every 2 h for 8 h post-exposure (750 mJ cm(-2)). The erythema index began to increase immediately post-UVR (P<0.05 at 4, 6 and 8 h), but CVC did not increase above baseline for the first 4-6 h (P <= 0.01 at 6 and 8 h); +SS prevented both responses. In study 2, in 13 healthy adults (24 +/- 4 years old; six men and seven women), three intradermal microdialysis fibres were placed in the ventral skin of the forearm [randomly assigned to UVR (450 mJ cm(-2)), UVR+SS or UVR+SW], and one fibre (non-exposed control; CON) was placed in the contralateral forearm. After UVR, a standardized local heating (42 degrees C) protocol quantified the percentage of NO-mediated vasodilatation (%NO). The UVR attenuated %NO compared with CON (P=0.01). The diminished %NO was prevented by +SS (P<0.01) and +SW (P<0.01). Acute broad-spectrum UVR attenuates NO-dependent dilatation in the cutaneous microvasculature, independent of erythema. Sunscreen protects against both inflammatory and heating-induced endothelial dysfunction, and sweat might prevent UVR-induced reductions in NO-dependent dilatation.
Details
- Title: Subtitle
- Sunscreen or simulated sweat minimizes the impact of acute ultraviolet radiation on cutaneous microvascular function in healthy humans
- Creators
- S. Tony Wolf - Pennsylvania State UniversityCraig W. Berry - Pennsylvania State UniversityAnna E. Stanhewicz - Pennsylvania State UniversityLauren E. Kenney - Pennsylvania State UniversitySara B. Ferguson - Penn State Milton S. Hershey Medical CenterW. Larry Kenney - Pennsylvania State University
- Resource Type
- Journal article
- Publication Details
- Experimental physiology, Vol.104(7), pp.1136-1146
- Publisher
- Wiley
- DOI
- 10.1113/EP087688
- PMID
- 31004462
- PMCID
- PMC6602818
- ISSN
- 0958-0670
- eISSN
- 1469-445X
- Number of pages
- 11
- Grant note
- American College of Sports Medicine Foundation T32AG049676 / NATIONAL INSTITUTE ON AGING; United States Department of Health & Human Services; National Institutes of Health (NIH) - USA; NIH National Institute on Aging (NIA) 5T-32-AG-049676 / NIH; United States Department of Health & Human Services; National Institutes of Health (NIH) - USA Penn State Dermatology Marks Endowment Fund
- Language
- English
- Date published
- 07/01/2019
- Academic Unit
- Fraternal Order of Eagles Diabetes Research Center; Health and Human Physiology; Internal Medicine
- Record Identifier
- 9984259391002771
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