Journal article
Sunscreen use and the risk for melanoma: A quantitative review
Annals of internal medicine, Vol.139(12), pp.966-978
2003
DOI: 10.7326/0003-4819-139-12-200312160-00006
PMID: 14678916
Abstract
Background: Originally developed to protect against sunburn, sunscreen has been assumed to prevent skin cancer. However, conflicting reports include claims that sunscreen increases risk for melanoma.
Objective: To examine the strength and consistency of associations between melanoma and sunscreen use in the published literature.
Data sources: A comprehensive MEDLINE search of articles published from 1966 to 2003 that reported information on sunscreen use and melanoma in humans.
Study selection: Analytic studies reporting data on sunscreen use before diagnosis of melanoma.
Data extraction: Two independent reviewers extracted data. Inconsistencies were rereviewed until agreement was achieved. When necessary, a third party resolved discrepancies.
Data synthesis: Odds ratios were pooled across studies by using standard meta-analytic techniques. Pooled odds ratios for ever use among 18 heterogeneous studies did not support an association between melanoma and sunscreen use. Variation among odds ratios was explained by studies that did not adjust for confounding effects of sun sensitivity. The lack of a dose-response effect with frequency of use (never, sometimes, or always) or years of use provided further evidence of a null association.
Conclusions: No association was seen between melanoma and sunscreen use. Failure to control for confounding factors may explain previous reports of positive associations linking melanoma to sunscreen use. In addition, it may take decades to detect a protective association between melanoma and use of the newer formulations of sunscreens.
Details
- Title: Subtitle
- Sunscreen use and the risk for melanoma: A quantitative review
- Creators
- Leslie K DENNIS - College of Public Health and College of Medicine, University of Iowa, Iowa City, Iowa, United StatesLaura E FREEMAN - College of Public Health and College of Medicine, University of Iowa, Iowa City, Iowa, United StatesMarta J VANBEEK - College of Public Health and College of Medicine, University of Iowa, Iowa City, Iowa, United States
- Resource Type
- Journal article
- Publication Details
- Annals of internal medicine, Vol.139(12), pp.966-978
- Publisher
- American College of Physicians; Philadelphia, PA
- DOI
- 10.7326/0003-4819-139-12-200312160-00006
- PMID
- 14678916
- ISSN
- 0003-4819
- eISSN
- 1539-3704
- Language
- English
- Date published
- 2003
- Academic Unit
- Dermatology; Epidemiology
- Record Identifier
- 9984025586502771
Metrics
26 Record Views