Journal article
Super-large bore catheter in the treatment of large vessel occlusions: initial multicenter experience
Journal of neurointerventional surgery, Vol.18(3), pp.790-796
03/2026
DOI: 10.1136/jnis-2025-023096
PMID: 40216535
Abstract
PurposeLarge bore catheters are increasingly used in mechanical thrombectomy (MT) for large vessel occlusions (LVOs).ObjectiveTo evaluate the efficacy and safety of the super-large bore Cereglide 0.092" (C-92) catheter, featuring the largest inner diameter available.MethodsA multicenter observational study was conducted across 12 comprehensive stroke centers in the United States. Efficacy outcomes included the first pass effect (FPE) and successful reperfusion. FPE was defined as a first MT pass achieving a modified Treatment in Cerebral Infarction (mTICI) score of ≥2c. Successful reperfusion was defined as final mTICI score ≥2c. Safety outcomes involved device-related complications, symptomatic intracranial hemorrhage (sICH), and inpatient mortality. Functional outcomes included modified Rankin Scale (mRS) score at discharge and delta National Institutes of Health Stroke Scale (NIHSS) score.ResultsFifty patients were included. The most common LVO was the first segment of the middle cerebral artery in 31/50 cases (62%). The C-92 reached the thrombus in 41 patients (82%). Median puncture-to-thrombus and puncture-to-reperfusion times were 15 min (IQR 10–25) and 26 min (IQR 15–49), respectively. FPE was achieved in 25/50 (50%) cases, and in 25/41 (61%) cases when the C-92 reached the thrombus. Successful reperfusion occurred in 36/41 patients (88%). There were no vessel perforations, or sICH. Distal embolization occurred in 4/50 (8%) cases, and 4/50 (8%) died. The mRS score at discharge was 3 (IQR 2–6), and the delta NIHSS score was 8 (IQR 5–12).ConclusionThe C-92 catheter demonstrated a safe profile achieving an overall FPE rate of 50%, and favorable functional outcomes in 88% of cases.
Details
- Title: Subtitle
- Super-large bore catheter in the treatment of large vessel occlusions: initial multicenter experience
- Creators
- Edgar A Samaniego - University of Iowa, Iowa Neuroscience InstituteAndres Gudino - University of IowaLeonardo Cruz-Criollo - University of IowaCarlos Dier - University of IowaBrian T Jankowitz - John F. Kennedy Medical CenterAishwarya Aggarwal - John F. Kennedy Medical CenterHaralabos Zacharatos - John F. Kennedy Medical CenterAlhamza R Al-Bayati - University of Pittsburgh Medical CenterRaul Nogueira - University of Pittsburgh Medical CenterMohamed F Doheim - University of Pittsburgh School of MedicineShahram Majidi - Icahn School of Medicine at Mount SinaiMichael T Froehler - Vanderbilt University Medical CenterMir Amaan Ali - Vanderbilt University Medical CenterRamesh Grandhi - University of UtahSantiago Gomez-Paz - University of UtahJaydevsinh Dolia - Emory UniversityJonathan A Grossberg - Emory University School of MedicineVinay Jaikumar - Department of Neurosurgery, University at Buffalo, Buffalo, New York, USAAdnan Siddiqui - Department of Neurosurgery, University at Buffalo, Buffalo, New York, USAAjit S Puri - University of Massachusetts SystemRaymond Catton - University of Massachusetts SystemJasmeet Singh - University of Massachusetts SystemSohyun Boo - West Virginia UniversityMohamad Ezzeldin - Department of Neuroendovascular Surgery, HCA Houston, Houston, Texas, USASantiago Ortega-Gutierrez - Department of Neurology, University of Iowa Hospitals and Clinics, Iowa City, Iowa, USAFawaz Al-Mufti - Westchester Medical Center
- Resource Type
- Journal article
- Publication Details
- Journal of neurointerventional surgery, Vol.18(3), pp.790-796
- DOI
- 10.1136/jnis-2025-023096
- PMID
- 40216535
- NLM abbreviation
- J Neurointerv Surg
- ISSN
- 1759-8478
- eISSN
- 1759-8486
- Publisher
- BMJ Publishing Group Ltd
- Language
- English
- Electronic publication date
- 04/11/2025
- Date published
- 03/2026
- Academic Unit
- Neurology; Radiology; Iowa Neuroscience Institute; Neurosurgery
- Record Identifier
- 9984808321002771
Metrics
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