Journal article
Superantigen Recognition by gamma delta T Cells: SEA Recognition Site for Human V gamma 2 T Cell Receptors
Immunity (Cambridge, Mass.), Vol.14(3), pp.331-344
03/01/2001
DOI: 10.1016/S1074-7613(01)00113-3
PMID: 11290341
Abstract
Human gamma delta T cells expressing the V gamma 2V delta 2 antigen receptors recognize nonpeptide prenyl pyrophosphate and alkylamine antigens. We find that they also recognize staphylococcal enterotoxin A superantigens in a manner distinct from the recognition of nonpeptide antigens. Using chimeric and mutant toxins, SEA amino acid residues 20-27 were shown to be required for gamma delta TCR recognition of SEA. Residues at 200-207 that are critical for specific alpha beta TCR recognition of SEA do not affect gamma delta TCR recognition. SEA residues 20-27 are located in an area contiguous with the binding site of V beta chains. This study defines a superantigen recognition site for a gamma delta T cell receptor and demonstrates the differences between V gamma 2V delta 2 super(+) T cell recognition of superantigens and nonpeptide antigens.
Details
- Title: Subtitle
- Superantigen Recognition by gamma delta T Cells: SEA Recognition Site for Human V gamma 2 T Cell Receptors
- Creators
- Craig T MoritaHongmin LiJames G LamphearRobert R RichJohn D FraserRoy A MariuzzaHoi K Lee
- Resource Type
- Journal article
- Publication Details
- Immunity (Cambridge, Mass.), Vol.14(3), pp.331-344
- DOI
- 10.1016/S1074-7613(01)00113-3
- PMID
- 11290341
- ISSN
- 1074-7613
- eISSN
- 1097-4180
- Language
- English
- Date published
- 03/01/2001
- Academic Unit
- Immunology; Internal Medicine
- Record Identifier
- 9984094315702771
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