Superantigen can reactivate bacterial cell wall-induced arthritis

John H Schwab; Roger R Brown; Sonia K Anderle; Patrick M Schlievert

doi:10.4049/jimmunol.150.9.4151

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Superantigen can reactivate bacterial cell wall-induced arthritis

Journal article

Peer reviewed

Superantigen can reactivate bacterial cell wall-induced arthritis

John H Schwab, Roger R Brown, Sonia K Anderle and Patrick M Schlievert

The Journal of immunology (1950), Vol.150(9), pp.4151-4159

05/01/1993

DOI: 10.4049/jimmunol.150.9.4151

PMID: 8473753

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Abstract

Intravenous injection of toxic shock syndrome toxin-1 (TSST-1) produced by Staphylococcus aureus, can reactivate arthritis in a rat ankle joint that has been previously inflamed by injection of peptidoglycanpolysaccharide polymers isolated from the cell walls of group A streptococci. The severity and chronicity of this renewed arthritis is dose dependent and at higher doses (125 micrograms/kg) a prolonged joint inflammation with pannus formation and marginal erosion of cartilage and bone is induced after a single injection of TSST-1. Only modest synovial hyperplasia is induced in control ankle joints by systemic injection of TSST-1. Another superantigen, streptococcal pyrogenic exotoxin induces a much weaker, acute reactivation of arthritis that resolves by 2 days. Repeated injections of TSST-1 at 7-day intervals give the same undiminished pattern of joint response, but the joint swelling persists at a higher level with each succeeding injection. Cyclosporin A suppresses all phases of the recurrent arthritis, indicating that TSST-1 could be functioning through its property of a superantigen activating T lymphocytes. II-1 receptor antagonist and anti-TNF-alpha neutralizing antibody, which reduce reactivation of arthritis by peptidoglycan-polysaccharide polymers, have no effect on reactivation by TSST-1. This experimental model provides a means to examine in vivo the possible role of superantigens in rheumatoid arthritis and related diseases, and to analyze the cellular and molecular pathways induced by this family of microbial products.

Recurrence

T-Lymphocytes - physiology

Cyclosporine - pharmacology

Exotoxins - immunology

Antigens, Bacterial - immunology

Rats, Inbred Lew

Polysaccharides, Bacterial - immunology

Rats

Arthritis, Infectious - pathology

Bacterial Proteins

Membrane Proteins

Animals

Enterotoxins - immunology

Bacterial Toxins

Sialoglycoproteins - pharmacology

Arthritis, Infectious - etiology

Superantigens

Female

Interleukin 1 Receptor Antagonist Protein

Staphylococcus aureus - immunology

Details

Title: Subtitle: Superantigen can reactivate bacterial cell wall-induced arthritis
Creators: John H Schwab - Department of Microbiology and Immunology, University of North Carolina School of Medicine, Chapel Hill 27599
Roger R Brown
Sonia K Anderle
Patrick M Schlievert
Resource Type: Journal article
Publication Details: The Journal of immunology (1950), Vol.150(9), pp.4151-4159
DOI: 10.4049/jimmunol.150.9.4151
PMID: 8473753
NLM abbreviation: J Immunol
ISSN: 0022-1767
eISSN: 1550-6606
Publisher: United States
Grant note: HL 36611 / NHLBI NIH HHS AR 39480 / NIAMS NIH HHS
Language: English
Date published: 05/01/1993
Academic Unit: Microbiology and Immunology; Internal Medicine
Record Identifier: 9984001124602771

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