Superficial papular neuroma: Case series of a new entity

Stephanie J T Chen; Rajiv M Patel; Christine P Hans; May P Chan; Douglas R Fullen

doi:10.1111/cup.12981

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Superficial papular neuroma: Case series of a new entity

Journal article

Open access

Peer reviewed

Superficial papular neuroma: Case series of a new entity

Stephanie J T Chen, Rajiv M Patel, Christine P Hans, May P Chan and Douglas R Fullen

Journal of cutaneous pathology, Vol.44(9), pp.757-762

09/2017

DOI: 10.1111/cup.12981

PMID: 28627021

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https://hdl.handle.net/2027.42/138273View

Open Access

Abstract

Dermal neural lesions arise in various circumstances and may be difficult to classify. We describe the clinical, histopathologic and immunophenotypic features of a series of terminally differentiated neural lesions not described previously, to our knowledge. Four cases from men aged 58 to 66 years were included. Some lesions reportedly bled, but no inciting trauma or prior biopsies were reported. None recurred after biopsy, with follow-up ranging from 19 to 113 months. All lesions were papular, with vertically oriented S100-positive spindled cells and nerve fibers in the papillary dermis. Slight epidermal hyperplasia, dilated superficial thin-walled vessels and minimal to mild inflammation were seen in each. Fibers were uniformly fine in 3 cases, with slightly thicker central fibers in the fourth. Three had parakeratotic scale. None were associated with dermal fibrosis or adnexal proliferation. Neurofilament stained axons in each. EMA was negative in all cases. CD34, melan-A and HMB45 were negative when performed. We report a small series of benign neural lesions and propose the name "superficial papular neuroma" for this distinct entity. Awareness is important to understand the clinical significance of these lesions and avoid misinterpretation that could lead to overtreatment, unnecessary work-up and increased cost.

Skin Neoplasms - pathology

Neuroma - pathology

Biomarkers, Tumor - analysis

Humans

Middle Aged

Male

Aged

Details

Title: Subtitle: Superficial papular neuroma: Case series of a new entity
Creators: Stephanie J T Chen - Department of Pathology, University of Michigan, Ann Arbor, Michigan
Rajiv M Patel - Department of Dermatology, University of Michigan, Ann Arbor, Michigan
Christine P Hans - Department of Pathology, Methodist Health System, Omaha, Nebraska
May P Chan - Department of Dermatology, University of Michigan, Ann Arbor, Michigan
Douglas R Fullen - Department of Dermatology, University of Michigan, Ann Arbor, Michigan
Resource Type: Journal article
Publication Details: Journal of cutaneous pathology, Vol.44(9), pp.757-762
DOI: 10.1111/cup.12981
PMID: 28627021
NLM abbreviation: J Cutan Pathol
ISSN: 0303-6987
eISSN: 1600-0560
Publisher: United States
Language: English
Date published: 09/2017
Academic Unit: Pathology
Record Identifier: 9984047743002771

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