Journal article
Superficial versus deep inguinal nodal dissection for vulvar cancer staging
Gynecologic oncology, Vol.166(3), pp.465-470
09/01/2022
DOI: 10.1016/j.ygyno.2022.06.024
PMID: 35781163
Abstract
Objective. The objective of this study was to compare the rate of groin recurrence among women undergoing superficial or deep inguinal lymph node dissections in suspected early-stage vulvar carcinoma. Secondary objec-tives included comparison of overall survival and post-operative morbidity between the study groups. Methods. A retrospective cohort of 233 patients with squamous cell carcinoma (SCC) of the vulva who under-went an inguinal lymph node dissection at two major academic institutions from 1999 to 2017 were analyzed. Demographic, surgical, recurrence, survival, and post-operative morbidity data were collected for 233 patients, resulting in a total of 400 groin node dissections analyzed.Results. Rates of overall primary recurrence of disease between superficial and deep inguinal LND (42.5 vs. 39.8%, p = 0.70) and rates of inguinal recurrence (3.4 vs. 8.3%, p = 0.16) were similar. Overall rates of postoper-ative morbidity were significantly higher in the cohort undergoing deep LND (70.3% vs 44.3%, p < 0.01). Rates of lymphedema (42.4 vs 15.9%, p < 0.01), readmission (26.3 vs 6.8%, p < 0.01), and infection (40.7 vs 14.8%, p < 0.01) were all significantly higher among patients undergoing deep LND. There was no significant difference noted in overall survival between the study groups when adjusting for stage and age (HR 1.08, p = 0.84). Conclusion. Superficial inguinal LND had no significant difference in rate of recurrence or overall survival when compared to deep inguinal LND in patients with vulvar SCC. Those who received a deep LND had a signif-icant increase in overall morbidity, including lymphedema, readmission, and infection. For patients who cannot undergo or fail sentinel lymph node mapping, a superficial inguinal lymph node dissection may have similar out-comes in recurrence and overall survival with a reduction in overall morbidity as compared to a complete, or deep, lymph node dissection.(c) 2022 Elsevier Inc. All rights reserved.
Details
- Title: Subtitle
- Superficial versus deep inguinal nodal dissection for vulvar cancer staging
- Creators
- Jordan Mattson - Department of Obstetrics and Gynecology, Division of Gynecologic Oncology, University of Minnesota, 515 Mayo Memorial Building, Moos Tower 12th Floor, Minneapolis, MN, United States of America. Electronic address: berne041@umn.edu.Jenna Emerson - Oregon Health & Science UniversityAmelia Underwood - United Family Physicians, Allina Health, St. Paul, MN, United States of America.Grace Sun - Brown UniversitySarah L. Mott - University of IowaAmita Kulkarni - Columbia UniversityKatina Robison - Brown UniversityEmily K. Hill - University of Iowa
- Resource Type
- Journal article
- Publication Details
- Gynecologic oncology, Vol.166(3), pp.465-470
- Publisher
- Elsevier
- DOI
- 10.1016/j.ygyno.2022.06.024
- PMID
- 35781163
- ISSN
- 0090-8258
- eISSN
- 1095-6859
- Number of pages
- 6
- Language
- English
- Date published
- 09/01/2022
- Academic Unit
- Obstetrics and Gynecology
- Record Identifier
- 9984318221802771
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