Superoxide Dismutases in Pancreatic Cancer

Justin G Wilkes; Matthew S Alexander; Joseph J Cullen

doi:10.3390/antiox6030066

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Superoxide Dismutases in Pancreatic Cancer

Journal article

Open access

Peer reviewed

Superoxide Dismutases in Pancreatic Cancer

Justin G Wilkes, Matthew S Alexander and Joseph J Cullen

Antioxidants, Vol.6(3), p.66

09/01/2017

DOI: 10.3390/antiox6030066

PMCID: PMC5618094

PMID: 28825637

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Abstract

The incidence of pancreatic cancer is increasing as the population ages but treatment advancements continue to lag far behind. The majority of pancreatic cancer patients have a K- ras oncogene mutation causing a shift in the redox state of the cell, favoring malignant proliferation. This mutation is believed to lead to nicotinamide adenine dinucleotide phosphate (NADPH) oxidase activation and superoxide overproduction, generating tumorigenic behavior. Superoxide dismutases (SODs) have been studied for their ability to manage the oxidative state of the cell by dismuting superoxide and inhibiting signals for pancreatic cancer growth. In particular, manganese superoxide dismutase has clearly shown importance in cell cycle regulation and has been found to be abnormally low in pancreatic cancer cells as well as the surrounding stromal tissue. Likewise, extracellular superoxide dismutase expression seems to favor suppression of pancreatic cancer growth. With an increased understanding of the redox behavior of pancreatic cancer and key regulators, new treatments are being developed with specific targets in mind. This review summarizes what is known about superoxide dismutases in pancreatic cancer and the most current treatment strategies to be advanced from this knowledge.

pancreatic cancer

superoxide dismutase

NADPH oxidase

manganese superoxide dismutase

Review

extracellular superoxide dismutase

superoxide

Details

Title: Subtitle: Superoxide Dismutases in Pancreatic Cancer
Creators: Justin G Wilkes - Departments of Surgery and Radiation Oncology, University of Iowa Carver College of Medicine, Iowa City, IA 52245, USA
Matthew S Alexander - Departments of Surgery and Radiation Oncology, University of Iowa Carver College of Medicine, Iowa City, IA 52245, USA
Joseph J Cullen - Departments of Surgery and Radiation Oncology, University of Iowa Carver College of Medicine, Iowa City, IA 52245, USA
Resource Type: Journal article
Publication Details: Antioxidants, Vol.6(3), p.66
DOI: 10.3390/antiox6030066
PMID: 28825637
PMCID: PMC5618094
NLM abbreviation: Antioxidants (Basel)
ISSN: 2076-3921
eISSN: 2076-3921
Publisher: MDPI
Language: English
Date published: 09/01/2017
Academic Unit: Surgery; Radiation Oncology
Record Identifier: 9984051787202771

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