Journal article
Supplemental B-Vitamins and Risk of Upper Gastrointestinal Cancers in the Women's Health Initiative
Nutrition and cancer, Vol.75(4), pp.1103-1108
2023
DOI: 10.1080/01635581.2023.2186258
PMID: 36895169
Abstract
B-vitamins contribute to DNA synthesis, maintenance, and regulation. Few studies have examined associations of supplemental sources of B-vitamins with the incidence of upper gastrointestinal (GI) cancers [including gastric (GCA) and esophageal (ECA) cancers]; the only prior study to comprehensively examine such intakes reported potential elevated risks of ECA. We examined 159,401 postmenopausal women, ages 50–79 years at baseline, including 302 incident GCA and 183 incident ECA cases, over 19 years of follow-up within the Women’s Health Initiative observational study and clinic trials. Adjusted Cox regression models estimated hazard ratios (HR) and 95% confidence intervals (CI) for associations of supplemental B-vitamins [riboflavin (B2), pyridoxine (B6), folic acid (B9), or cobalamin (B12)] with GCA and ECA risk, respectively. Although HRs were generally below 1.0, we observed no statistically significant associations between supplemental intakes of any of the evaluated B-vitamins with the risk of GCA or ECA. As the first prospective study to comprehensively assess these associations, our findings do not corroborate prior research indicating potential harm from supplemental B-vitamin intake for upper GI cancer risk. This study adds evidence that supplemental intakes of B-vitamins may be used by postmenopausal women without regard to their relationship with upper GI cancer risk.
Details
- Title: Subtitle
- Supplemental B-Vitamins and Risk of Upper Gastrointestinal Cancers in the Women's Health Initiative
- Creators
- Theodore M. Brasky - The Ohio State UniversityRoberta M. Ray - Women's Health InitiativeAlison M. Newton - The Ohio State UniversitySandi L. Navarro - Fred Hutch Cancer CenterJeannette M. Schenk - Fred Hutch Cancer CenterHolli A. Loomans-Kropp - The Ohio State UniversityRhonda S. Arthur - Albert Einstein College of MedicineLinda G. Snetselaar - University of IowaJohn Hays - The Ohio State UniversityMarian L. Neuhouser - Fred Hutch Cancer Center
- Resource Type
- Journal article
- Publication Details
- Nutrition and cancer, Vol.75(4), pp.1103-1108
- Publisher
- Taylor & Francis
- DOI
- 10.1080/01635581.2023.2186258
- PMID
- 36895169
- ISSN
- 0163-5581
- eISSN
- 1532-7914
- Grant note
- name: National Heart, Lung, and Blood Institute, National Institutes of Health and U.S. Department of Health and Human Services, award: HHSN2682011000046C, HHSN268201100001C, HHSN268201100002C, HHSN268201100003C, HHSN268201100004C
- Language
- English
- Electronic publication date
- 03/09/2023
- Date published
- 2023
- Academic Unit
- Epidemiology; Fraternal Order of Eagles Diabetes Research Center; Internal Medicine
- Record Identifier
- 9984375356602771
Metrics
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